DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	129/530 - (24%)
Similarity:	220/530 - (41%)	Gaps:	123/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPLVLFILLAATLLFWKWQGNH----WRRLGLEAPFGWPLVGNMLDFALG--------RRSYGEI 54
            |.|..::|||..|:.....|..    :::.|:..|...|..|.:|::.:|        .:.||:|
  Rat     7 LTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDVECHKKYGKI 71

  Fly    55 YQEIYTRNPGLKYVGFYRLFN--EPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHN 117
                            :.||:  .|...:.|.|:::.:||...|:              |..:..
  Rat    72 ----------------WGLFDGQMPLFAITDTEMIKNVLVKECFS--------------VFTNRR 106

  Fly   118 PF-----------IANGDRWRVLRADLVPLFTPSRVRQTLPHVAR----ACQLLRDQ----VPLG 163
            .|           ::..:.|:..||.|.|.||..|:::..|.:.:    ..:.||.:    ||:
  Rat   107 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEKGKPVPV- 170

  Fly   164 RFEAKDLATRYTLQVVASAIFGLDAHCLGIHMRVAHEPSRWL---EWLAPLFQ-----PSVWSLL 220
                |::...|::.|:.|..||::...|........|.::.|   ::..|||.     |.:..:.
  Rat   171 ----KEVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVY 231

  Fly   221 ETMSLLHTP-----------------RLGRLIGHRYVPLPLQHWFRELVEARSGGDNLLQWLAES 268
            |.:::...|                 ||..:..||...|.|      ::.|.:...:     .||
  Rat   232 EMLNICMFPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQL------MMNAHNDSKD-----KES 285

  Fly   269 KRGLGKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVA 333
            ...|...|:...:...:..|||.::..|:|.|:.||.:.|.|::|..|:|......|....|.|.
  Rat   286 HTALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVM 350

  Fly   334 LGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPA 398
              |:.|.:..|.|.|||:|....|::.|.|...:        :.:.:..|:|:::|..|:|.||.
  Rat   351 --EMEYLDMVLNETLRLYPIGNRLERVCKKDVEI--------NGVFMPKGSVVMIPSYALHRDPQ 405

  Fly   399 LYPAPNQFRPERFLNQ------PPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLA 457
            .:|.|.:||||||..:      |.:   :|.||.|||.|.|||..|:..|.|||.:||:...|..
  Rat   406 HWPEPEEFRPERFSKENKGSIDPYV---YLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPC 467

  Fly   458 DEDQCRVEVS 467
            .|.|..:::|
  Rat   468 KETQIPLKLS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	121/496 (24%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	121/498 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920