DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp308a1 and erg5

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	578	Identity:	110/578 - (19%)
Similarity:	199/578 - (34%)	Gaps:	181/578 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLFILLAATLLF----WKWQGNHWRRLGLEAP-FGWPLVGNMLDFALGRRSYGEIYQEIYTRNPG 64
            :.|.|||..:.:    ::.|..|     :..| |..|.:|:.||   ..:...|.|...:...|
pombe    31 ICFALLAVCIAYDQISYQMQKGH-----IPGPRFKIPFMGSFLD---SMKPTFEKYNAKWQTGP- 86

  Fly    65 LKYVGFYRLFNEPAILVRDQELLRQILVGRNFAD-CADNAVYVDHQRDVLASHNPFIANGDRWRV 128
            |..|..:..|   .::..:::|.|:||...::.. |.     ||..:.:|...|....:|.....
pombe    87 LSCVSVFHKF---VVIASERDLARKILNSPSYVQPCV-----VDAGKKILKHTNWVFLDGRDHIE 143

  Fly   129 LRADLVPLFTPSRVRQTLPHVARACQLLRDQVPLGRFEAKDLATRYTLQVVASAIFGLDAHCLGI 193
            .|..|..|||...:...||                  ..:.:..:|..:.
pombe   144 YRKGLNGLFTTRALASYLP------------------AQEAVYNKYFKEF--------------- 175

  Fly   194 HMRVAHEPSRWLEWLAPLFQPSV------------------------WSLLETMSLLHTPRL--- 231
               :||....:.:::.|....:|                        |.:...|.|::.|.:
pombe   176 ---LAHSKDDYAQYMIPFRDINVATSCRTFCGYYISDDAIKHIADEYWKITAAMELVNFPIVLPF 237

  Fly   232 --------GRLIGHRYV-----------------PLPLQHWFRELVEARSGGDNLLQWLAESKRG 271
                    .|.:..||.                 ...::.|..|::|.|       ::.:|:|.|
pombe   238 TKVWYGIQSRKVVMRYFMKAAAESRKNMEAGNAPACMMEEWIHEMIETR-------KYKSENKEG 295

  Fly   272 LGK----------EELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAG 326
            ..|          ||::....:.|....:.::..:.:....||.:.|..:::.   :|..:...|
pombe   296 AEKPSVLIREFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVR---EEQLRIRKG 357

  Fly   327 NLIDPVALG---ELRYSEAALLEALRLHPAMQALQKRCTKTFTL-PDQKSGASSELKVHLGTV-- 385
            ::..|::|.   ::.|:.|.:.|.|||.|.:..:..|..|.|.: ||.             ||
pombe   358 DIDVPLSLDLMEKMTYTRAVVKECLRLRPPVLMVPYRVKKAFPITPDY-------------TVPK 409

  Fly   386 --LVLPV--QAIHLDPALYPAPNQFRPERF-----LNQPPMGCRFLGFGAGPRMCPGMRLGLLQT 441
              :|:|.  .|:| |..:||.|..|.|:|:     ..|.|.  .::.||.||.:|.|.|..:...
pombe   410 DAMVIPTLYGALH-DSKVYPEPETFNPDRWAPNGLAEQSPK--NWMVFGNGPHVCLGQRYAVNHL 471

  Fly   442 KAAL---TTLLQ-------DHCVQLA-----DEDQCRVEVSPLTFLTASRNGIWLSFK 484
            .|.:   :.:|.       |...|:.     .:|.|.::.||....|..    |.:.|
pombe   472 IACIGKASIMLDWKHKRTPDSDTQMIFATTFPQDMCYLKFSPFDASTVD----WKNSK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	102/542 (19%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	97/521 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050