DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	140/570 - (24%)
Similarity:	240/570 - (42%)	Gaps:	135/570 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPLVLFILLAATLLFWKWQG----NHWRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYTR 61
            ::.:.|.::|.|.|   ||..    :..|:||:..|...|.|||::.|   |:.:.|.:.|:..|
  Rat    15 VVTVTLSVVLLALL---KWYSTSAFSRLRKLGIRHPEPSPFVGNLMFF---RQGFWESHLELRER 73

  Fly    62 NPGLKYVGFY---RLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPFIANG 123
            ...|  .|:|   |::    |::.|.::::::|| .||::.::.  ........|.:.:..:...
  Rat    74 YGPL--CGYYLGRRMY----IVISDPDMIKEVLV-ENFSNFSNR--MASGLEPKLIADSVLMLRD 129

  Fly   124 DRWRVLRADLVPLFTPSRVRQTLPHVARACQLLRDQV--PLGRFEAKDLATRY---TLQVVASAI 183
            .||..:|..|:..|:|.::.:..|.:::||:||...:  .....:|.|:...|   |..||||..
  Rat   130 RRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVA 194

  Fly   184 FGLDA------------HCLGIHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRLIG 236
            ||::.            ||           .|...:..|  :|.:..:|...|:: .| |.|::.
  Rat   195 FGIEVNSQDAPEDPFVQHC-----------QRVFAFSTP--RPLLALILSFPSIM-VP-LARILP 244

  Fly   237 HRYVPLPLQHWFRELV------------EARSGGDNLLQWLAESKRGLGK--------------- 274
            ::... .|..:|..|:            |.|.|  :.||.:.:::|.:..
  Rat   245 NKNRD-ELNGFFNTLIRNVIALRDKQTAEERRG--DFLQMVLDAQRSMSSVGVEAFDMVTEALSS 306

  Fly   275 ----------------------EELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIEL 317
                                  :|:||.|...|:.|:|.:...|:|..|.||.:.:.|.||..|:
  Rat   307 AECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEV 371

  Fly   318 DEVAQRHAG----NLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSEL 378
            |...::|..    ||.:     .|.|.:..:.|.||::|          ..|....:.:.....|
  Rat   372 DLFMEKHPAPEYCNLQE-----GLPYLDMVVAETLRMYP----------PAFRFTREAAQDCEVL 421

  Fly   379 KVHL--GTVLVLPVQAIHLDPALYPAPNQFRPERF-----LNQPPMGCRFLGFGAGPRMCPGMRL 436
            ..|:  |:||.:.|.|:|.||..:|.|..|.||||     |.|.|.  .:|.||||||.|.|:||
  Rat   422 GQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPF--TYLPFGAGPRSCLGVRL 484

  Fly   437 GLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKRR 486
            |||..|..|..:|.....:...|.|..:::...:.| ..:||:::....|
  Rat   485 GLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSAL-CPKNGVYVKIVSR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	130/528 (25%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	130/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780