Protein Alignment Cyp308a1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_573320.1
• Gene: Cyp308a1 / 32859
• FlyBaseID: FBgn0030949
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 134/544 - (24%)
• Similarity: 235/544 - (43%)
• Gaps: 119/544 - (21%)

  Fly     2 LPLVLFILLAATLLFWKWQGNH----WRRLGLEAPFGWPLVGNMLDFALG--------RRSYGEI 54
            |.:..::|||.:|:.....|.|    :::||:..|...|.:||:|.:..|        .:.||::
Human     7 LAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKV 71

  Fly    55 YQEIYTRNPGLKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPF 119
            :             |||. ..:|.:.:.|.::::.:||...::              |..:..||
Human    72 W-------------GFYD-GQQPVLAITDPDMIKTVLVKECYS--------------VFTNRRPF 108

  Fly   120 -----------IANGDRWRVLRADLVPLFTPSRVRQTLPHVAR----ACQLLRDQVPLGR-FEAK 168
                       ||..:.|:.||:.|.|.||..::::.:|.:|:    ..:.||.:...|: ...|
Human   109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK 173

  Fly   169 DLATRYTLQVVASAIFGLDAHCLGIHMRVAHEPSRWL---EWLAPLFQ-----PSVWSLLETMSL 225
            |:...|::.|:.|..||::...|........|.::.|   ::|.|.|.     |.:..:||.:::
Human   174 DVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNI 238

  Fly   226 LHTP-----------------RLGRLIGHRYVPLPLQHWFRELVEARSGGDNLLQWLAESKRGLG 273
            ...|                 ||.....||...|.|      ::::::..:      .||.:.|.
Human   239 CVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQL------MIDSQNSKE------TESHKALS 291

  Fly   274 KEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELR 338
            ..||...:...:..||||::.:|:|.:||||.:.|.|::|..|:|.|....|....|.|.  ::.
Human   292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL--QME 354

  Fly   339 YSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAP 403
            |.:..:.|.|||.|....|::.|.|...:        :.:.:..|.|:::|..|:|.||..:..|
Human   355 YLDMVVNETLRLFPIAMRLERVCKKDVEI--------NGMFIPKGVVVMIPSYALHRDPKYWTEP 411

  Fly   404 NQFRPERFL-----NQPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCR 463
            .:|.||||.     |..|.  .:..||:|||.|.|||..|:..|.||..:||:...:...|.|..
Human   412 EKFLPERFSKKNKDNIDPY--IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474

  Fly   464 VEVS---------PLTFLTASRNG 478
            :::|         |:.....||:|
Human   475 LKLSLGGLLQPEKPVVLKVESRDG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	125/510 (25%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	122/505 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920