Protein Alignment Cyp18a1 and ERG11

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 562
• Identity: 121/562 - (21%)
• Similarity: 219/562 - (38%)
• Gaps: 133/562 - (23%)

  Fly    23 AQHLLMVFLGLLALVTLLQW-LVRNYRELRKLPP--GPWGLPVIGYLLFMGSEKHTRFMELAKQY 84
            ||.:.::.  ::..:..:.| |:.:.|:.|  ||  ..| :|.:|..:..|.:.:..|.|..|:|
Yeast    28 AQRISLII--IIPFIYNIVWQLLYSLRKDR--PPLVFYW-IPWVGSAVVYGMKPYEFFEECQKKY 87

  Fly    85 GSLFS-TRLGSQLTVVMSDYKMIRECFRREEFT--------------GRPDTPFMQTLNGYGII- 133
            |.:|| ..||..:||.:..        :..||.              ....||..    |.|:|
Yeast    88 GDIFSFVLLGRVMTVYLGP--------KGHEFVFNAKLADVSAEAAYAHLTTPVF----GKGVIY 140

  Fly   134 NSTGKLWKDQRRFLHDKL-RQFGMTYMGNGKQQMQKRIMTEVHEFIG-----HLHASDGQPVDM- 191
            :.......:|::|:...| ::...:|:        ..|..||:::..     .|:......:|:
Yeast   141 DCPNSRLMEQKKFVKGALTKEAFKSYV--------PLIAEEVYKYFRDSKNFRLNERTTGTIDVM 197

  Fly   192 --SPVISV-AVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST 253
              .|.::: ..|..:....|..:...|      |.:|..:..:.|..|:.|        ||::..
Yeast   198 VTQPEMTIFTASRSLLGKEMRAKLDTD------FAYLYSDLDKGFTPINFV--------FPNLPL 248

  Fly   254 ---AKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDG-KNH 314
               .|...||.  .:...|..:|.:.:::.|..: |||:|..:          .::...|| |..
Yeast   249 EHYRKRDHAQK--AISGTYMSLIKERRKNNDIQD-RDLIDSLM----------KNSTYKDGVKMT 300

  Fly   315 EEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVV--GRHRLPTIEDLQYLP 377
            ::::..::|.:...|..|...|..||.:.:...|...:.:.:|..:|:  |:..| |.:.||.:|
Yeast   301 DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKEL-TYDLLQEMP 364

  Fly   378 ITESTILESMRRSSIVPLATTHSPTRDVELN------GYTIPAGSHVIPLINSVHMDPNLWEKPE 436
            :...||.|::|...  ||   ||..|.|..:      .|.||||.||:......|:....:....
Yeast   365 LLNQTIKETLRMHH--PL---HSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAH 424

  Fly   437 EFRPSRF-------------ID------TEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFAS 482
            :|...|:             :|      ::| |..|  ::|||.||..|:|:..|..:|.:..:.
Yeast   425 QFNIHRWNKDSASSYSVGEEVDYGFGAISKG-VSSP--YLPFGGGRHRCIGEHFAYCQLGVLMSI 486

  Fly   483 FMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGP 524
            |:.......|||:           |:.|..| ..:...|.||
Yeast   487 FIRTLKWHYPEGK-----------TVPPPDF-TSMVTLPTGP 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	102/486 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	107/502 (21%)