Protein Alignment Cyp18a1 and DIT2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_010690.1
• Gene: DIT2 / 852011
• SGDID: S000002810
• Length: 489
• Species: Saccharomyces cerevisiae
• Alignment Length: 534
• Identity: 106/534 - (19%)
• Similarity: 206/534 - (38%)
• Gaps: 146/534 - (27%)

  Fly    33 LLALVTLLQWLVRNYRELRKLPPG---PWGLPVIG-YLLFM-------GSEKHTRFM-ELAKQYG 85
            ||.|:.|:.:|..:|.....:.|.   |..:|.|. |::|:       .:|.:..:: |..::||
Yeast     3 LLKLLCLILFLTLSYVAFAIIVPPLNFPKNIPTIPFYVVFLPVIFPIDQTELYDLYIRESMEKYG 67

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDT----PF--MQTLNGYGIINSTGKLWKDQR 144
            :: ....||:..:::|..:.:.:.|:.|:...:...    |:  :....|..:|::.|.:|::.|
Yeast    68 AV-KFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVISAYGAVWRNYR 131

  Fly   145 RFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLM-- 207
            ..:.:.|:.|                                   |.:|:...|  .::|:|:
Yeast   132 NAVTNGLQHF-----------------------------------DDAPIFKNA--KILCTLIKN 159

  Fly   208 -------------MSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIA 259
                         :|.|.::|:                      :..:.....|.:::..||...
Yeast   160 RLLEGQTSIPMGPLSQRMALDN----------------------ISQVALGFDFGALTHEKNAFH 202

  Fly   260 QN--RAEMQRF--------YQDV--IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTD------- 305
            ::  |.:.|.|        :.||  |...|::|     :|:|.|....:::.:.|..:
Yeast   203 EHLIRIKKQIFHPFFLTFPFLDVLPIPSRKKAF-----KDVVSFRELLVKRVQDELVNNYKFEQT 262

  Fly   306 ----AELFDGKNHE----EQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVV 362
                ::|....|:|    :||...|:.:..||.|..:   |..|..:....|.....|::|.:.|
Yeast   263 TFAASDLIRAHNNEIIDYKQLTDNIVIILVAGHENPQ---LLFNSSLYLLAKYSNEWQEKLRKEV 324

  Fly   363 GRHRLPTIEDLQYLPITESTILESMRR----SSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN 423
            .....|  :.|..||:..:.:.|.:|.    |:|:...||.:.....|:   .||.|.:|.....
Yeast   325 NGITDP--KGLADLPLLNAFLFEVVRMYPPLSTIINRCTTKTCKLGAEI---VIPKGVYVGYNNF 384

  Fly   424 SVHMDPNLW-EKPEEFRPSRF---IDT---EGKVRKPEYFIP-FGVGRRMCLGDVLARMELFLFF 480
            ....||..| ...::|:|.|:   |:|   ..::.|....:. |..|||.|||:.||..|:.:..
Yeast   385 GTSHDPKTWGTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISL 449

  Fly   481 ASFMHCFDIAL-PE 493
            |..:..|..:| ||
Yeast   450 AEMLKQFRWSLDPE 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	91/470 (19%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	92/472 (19%)