DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP703A2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_171635.1	Gene:	CYP703A2 / 839470	AraportID:	AT1G01280	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	527	Identity:	142/527 - (26%)
Similarity:	234/527 - (44%)	Gaps:	65/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFST 90
            |..:|..|:..|.|.:||..:..:.::|||||..||::|.||.:|...|.....|..:||.|...
plant     5 LASLFAVLILNVLLWRWLKASACKAQRLPPGPPRLPILGNLLQLGPLPHRDLASLCDKYGPLVYL 69

  Fly    91 RLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTLNGYG----IINSTGKLWKDQRRFLHD 149
            |||:...:..:|...|||...|::  |:.||.|.....| .||    .:...|..||..||...:
plant    70 RLGNVDAITTNDPDTIREILLRQDDVFSSRPKTLAAVHL-AYGCGDVALAPMGPHWKRMRRICME 133

  Fly   150 ------KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMM 208
                  :|..|     ...:.:..:.::.:|.:     .:..|:|:::..|:.....|.:..:::
plant   134 HLLTTKRLESF-----TTQRAEEARYLIRDVFK-----RSETGKPINLKEVLGAFSMNNVTRMLL 188

  Fly   209 STRF----SIDDPK-FRRFNFLIEEGMRLFGEIHTVDYIPTMQCF-PSISTAKNKIAQNRAEMQR 267
            ..:|    |:..|| .:.|..:..:...|.|.|:..||:|..:.. ||....:.:..:.|.:  .
plant   189 GKQFFGPGSLVSPKEAQEFLHITHKLFWLLGVIYLGDYLPFWRWVDPSGCEKEMRDVEKRVD--E 251

  Fly   268 FYQDVIDDHKRS----FDPNNIRDLVDFYL-CEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFS 327
            |:..:||:|:|:    .|.|...|.||..| ...|..||...|.|:       :.|:|   |:.:
plant   252 FHTKIIDEHRRAKLEDEDKNGDMDFVDVLLSLPGENGKAHMEDVEI-------KALIQ---DMIA 306

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            |..:|...|..|.....::.|:.||::|:|||.|||.:|:....||.:|......:.|:.|....
plant   307 AATDTSAVTNEWAMAEAIKQPRVMRKIQEELDNVVGSNRMVDESDLVHLNYLRCVVRETFRMHPA 371

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVR-----K 452
            .|....|...|...:|||.|||.:.|....:.:..:..:|:..|:|||.|....||..|     .
plant   372 GPFLIPHESVRATTINGYYIPAKTRVFINTHGLGRNTKIWDDVEDFRPERHWPVEGSGRVEISHG 436

  Fly   453 PEY-FIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:: .:||..|:|.|.|..|....:.:..|...|||:.:.|         ||:.   |.|.:.:.
plant   437 PDFKILPFSAGKRKCPGAPLGVTMVLMALARLFHCFEWSSP---------GNID---TVEVYGMT 489

  Fly   517 L-KRRPL 522
            : |.:||
plant   490 MPKAKPL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	131/491 (27%)
CYP703A2	NP_171635.1	PLN03112	1..510	CDD:215583	142/527 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	186	1.000	Domainoid score	I986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I1368
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050