DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c23

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_114027.2	Gene:	Cyp2c23 / 83790	RGDID:	620370	Length:	494	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	166/502 - (33%)
Similarity:	280/502 - (55%)	Gaps:	28/502 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LGLLALVTLLQWLVRNYRELR---KLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTR 91
            |.|:..||.|. |:..:.:||   :|||||..||:||.||.:. .:......:|||:||.:::..
  Rat     9 LALVVSVTCLS-LLSVWTKLRTRGRLPPGPTPLPIIGNLLQLNLKDIPASLSKLAKEYGPVYTLY 72

  Fly    92 LGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKLRQ 153
            .|:..|||:..|.:::|..  :.:||.||...|.:: |..|||:|.|.|:.||..|||....||.
  Rat    73 FGTSPTVVLHGYDVVKEALLQQGDEFLGRGPLPIIEDTHKGYGLIFSNGERWKVMRRFSLMTLRN 137

  Fly   154 FGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPK 218
            |||     ||:.:::|:..|....:..|..:..||.|.:.:::.|..|||||::.:.||..::..
  Rat   138 FGM-----GKRSLEERVQEEARCLVEELQKTKAQPFDPTFILACAPCNVICSILFNDRFQYNNKT 197

  Fly   219 FRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSI---STAKN-KIAQNRAEMQRFYQDVIDDHKRS 279
            |.....|:.:.   |.::::| :......:|:|   ...|: :.|:...:::.|..:.:.:|::|
  Rat   198 FLNLMDLLNKN---FQQVNSV-WCQMYNLWPTIIKYLPGKHIEFAKRIDDVKNFILEKVKEHQKS 258

  Fly   280 FDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            .||.|.||.:|.:|.:||:.| :...:|.     |.|.|.....:||:||.||..|||.:..:.:
  Rat   259 LDPANPRDYIDCFLSKIEEEK-DNLKSEF-----HLENLAVCGSNLFTAGTETTSTTLRFGLLLL 317

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            ::.|:...:|.:|||:|:|||:.|:::|...||.|::.:.|..|..:::|.:..|:..:|.:...
  Rat   318 MKYPEVQAKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRD 382

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            |.||.|:.|:|:::||.:|...:..||:|.|..|:|..|..:|.:||:||.:|:|.|:|:.||||
  Rat   383 YVIPKGTTVLPMLSSVMLDQKEFANPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRACVGESLARM 447

  Fly   475 ELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            ||||||.:.:..|.: .|.|.:.|.......|....|..:|:||..|
  Rat   448 ELFLFFTTLLQKFSLKTLVEPKDLDIKPITTGIINLPPPYKLCLVPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	154/471 (33%)
Cyp2c23	NP_114027.2	p450	34..491	CDD:278495	154/471 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820