DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP84A4

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_196053.2	Gene:	CYP84A4 / 830312	AraportID:	AT5G04330	Length:	512	Species:	Arabidopsis thaliana

Alignment Length:	508	Identity:	149/508 - (29%)
Similarity:	235/508 - (46%)	Gaps:	73/508 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQW-----LVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGS 86
            ::..:.|:.||.||.:     |:|....|:..||||.||||||.:|.|....|....:|::.||.
plant     1 MLTLMTLIVLVPLLLFLFPHLLLRRQMLLKPYPPGPKGLPVIGNILMMNQFNHRGLAKLSRIYGG 65

  Fly    87 LFSTRLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTLNGYG----IINSTGKLWKDQRR 145
            |...|||.....|:|...:.|:..:.::  |:.||.|..::.|. ||    ...:.|..|:..|:
plant    66 LLHLRLGFSHIFVVSSPDIARQVLQVQDHVFSNRPTTIAIRYLT-YGGSDLAFCNYGPFWRRMRK 129

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            .       :.|......:.:....:..|||:.:..:.::.|:|::            ||.|..|.
plant   130 L-------YVMMLFSRKRAESWVSVDEEVHKSVRLVASNVGKPLN------------ICKLAFSL 175

  Fly   211 RFSI-------------DDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNR 262
            ...|             |:.:...|..:|:|..:||||.:..||:|:...:........::.:.|
plant   176 SRDITFRAAFGSSSSTSDESRLDEFLEIIQEFSKLFGEFNVADYVPSWLSWIDPQGINGRVEKAR 240

  Fly   263 AEMQRFYQDVIDD--HKRSFDPNNI---RDLVD----FYLCEIEKAKAEGTDAELFDGKNHEEQL 318
            ..:..|.:.||||  ||:..:.:|:   .|:||    ||..|: |.....|...|       :.:
plant   241 KSLDGFIESVIDDHLHKKKREHDNVDEETDMVDQLLAFYEEEV-KVNNSVTKINL-------DNI 297

  Fly   319 VQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIED--LQYLPITES 381
            ..:|:|:...|.||:...:.|:...:||:|:.|:||||||..|||..|. .:||  |:.|...:.
plant   298 KGIIMDVMFGGTETVALAIEWVLTEILRSPENMKRVQDELTSVVGLDRW-RVEDTHLEKLTFLKC 361

  Fly   382 TILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFI-- 444
            .:.|::|.....|| ..|...:|.|::||.||.||.|:....::..|||.|..||.|.|.||:
plant   362 ILKETLRLHPPFPL-LLHETVKDTEISGYFIPKGSRVMVNTYALGRDPNSWSDPESFNPGRFLNP 425

  Fly   445 ---DTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG 494
               |.:|...:   |:|||.|||.|.|..|......|..|..:|||..:||:|
plant   426 IAPDLKGNNFE---FVPFGSGRRSCPGMQLGLYAFELAVAHLLHCFTWSLPDG 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	141/476 (30%)
CYP84A4	NP_196053.2	p450	31..509	CDD:416425	141/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	186	1.000	Domainoid score	I986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77704
Inparanoid	1	1.050	192	1.000	Inparanoid score	I1368
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960