DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP71B25

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_189258.1	Gene:	CYP71B25 / 822230	AraportID:	AT3G26270	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	237/527 - (44%)	Gaps:	61/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTL--LQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLF 88
            :|..||.||:|..|  |.:..:.....|.|||||..||::|.|..:....|....||:|::|.:.
plant     3 ILQSFLLLLSLPFLFTLIYTKKMKESKRNLPPGPAKLPIVGNLHQLQGMVHRCLHELSKKHGPVM 67

  Fly    89 STRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLN------GYGIINSTGKLWKDQRR 145
            ..:||....|::|..:...|..:..  |...||:|...:..:      |.|..:..   |::.|:
plant    68 HLQLGFVPLVLISSSEAAEEALKTHDIECCTRPNTNAARVFSRNNKNIGLGAYSDE---WRELRK 129

  Fly   146 ------FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVIC 204
                  |...|::.|  .|:...:..:..:.:.::        |....|||:|..:....::.:.
plant   130 VAVREYFSVKKVQSF--RYVREEENHLMVKKLRDL--------ALKQSPVDLSKTLFCLAASTVF 184

  Fly   205 SLMMSTRFS----IDDPKFRRFNFLIEEGMRL-FGEIHTVDYIPTMQCFPSISTAKNK-IAQNRA 263
            ..:....||    ..:.|.....|..::.:.. |.::..   ||.:..|....:.::| :.:...
plant   185 RPVFGQSFSDNKHFSEEKIEELVFEAQKSLTFKFSDLFP---IPGLGWFIGFVSGQHKGLHKVFI 246

  Fly   264 EMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSA 328
            |:..|...:||||::...|.:..|:|...|..|...:.:.:.....|   |.:.:.|   |:|.|
plant   247 EVDNFLNHMIDDHQKQNQPQDRSDIVGSLLDMIHNQEQDKSFKLTID---HLKGITQ---DIFLA 305

  Fly   329 GMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVG--RHRLPTIED---LQYLPITESTILESMR 388
            |::|...|::|....::.||:.|::||||:...:|  :.|:.. ||   ||||.:   .|.|::|
plant   306 GIDTSAITMIWAMAELVNNPRVMKKVQDEIRSCIGIKKERIEE-EDVGKLQYLKL---VIKETLR 366

  Fly   389 RSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKP 453
            .....||........|:::.||.||..:.::....|:..||..|:.||||.|.||||.....:..
plant   367 LHPAAPLLLPRETMADIKIQGYDIPRKTLLLVSAWSLGRDPKYWKNPEEFNPERFIDCPVDYKGH 431

  Fly   454 EY-FIPFGVGRRMCLG--DVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKV 515
            .: |:|||.|||.|.|  ..:|.:||.|.  :.::.||..|||.....:::.:...||..   ||
plant   432 SFEFLPFGSGRRFCPGMASAIATIELTLL--NLLYFFDWKLPEEMKDMNMEESGDVTIVK---KV 491

  Fly   516 CLKRRPL 522
            .|:..|:
plant   492 PLELLPV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	125/490 (26%)
CYP71B25	NP_189258.1	p450	26..497	CDD:299894	128/501 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900