DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and CYP71B3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_189253.1	Gene:	CYP71B3 / 822223	AraportID:	AT3G26220	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	141/543 - (25%)
Similarity:	235/543 - (43%)	Gaps:	81/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRE-LRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFS 89
            :|:.|..|..:::|:  .::.::: .|.|||.|..||:||.|..:....|....:|:|::|.:..
plant     3 ILLYFFFLPVILSLI--FMKKFKDSKRNLPPSPPKLPIIGNLHQLRGLFHRCLHDLSKKHGPVLL 65

  Fly    90 TRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNGYG---IINSTGKLWKDQRR---- 145
            .|||....||:|..:...|..:..  |...||.|......:..|   .....|::.::.|:
plant    66 LRLGFIDMVVISSKEAAEEVLKVHDLECCTRPKTNASSKFSRDGKDIAFAPYGEVSRELRKLSLI 130

  Fly   146 --FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMM 208
              |...|:|.|  .|:...:..:..:.:.|        .|.....||:|..:...|.::|.....
plant   131 NFFSTQKVRSF--RYIREEENDLMVKKLKE--------SAKKKNTVDLSQTLFYLVGSIIFRATF 185

  Fly   209 STRFS----IDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS--------ISTAKNKIAQN 261
            ..|..    ::..|       |||   |..|:..|..:.:...||:        :|.....:.:.
plant   186 GQRLDQNKHVNKEK-------IEE---LMFEVQKVGSLSSSDIFPAGVGWFMDFVSGRHKTLHKV 240

  Fly   262 RAEMQRFYQDVIDDH-KRSFDPNN--IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVII 323
            ..|:......|||.| |...|..|  ..|::|..|..|.|.:.:    |.|  |...:.|..:|.
plant   241 FVEVDTLLNHVIDGHLKNPEDKTNQDRPDIIDSILETIYKQEQD----ESF--KLTIDHLKGIIQ 299

  Fly   324 DLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIED-----LQYLPITESTI 383
            :::.||::|...|::|....:::||:.|::.|:|:...:|..:...||:     ||||.:   .|
plant   300 NIYLAGVDTSAITMIWAMAELVKNPRVMKKAQEEIRTCIGIKQKERIEEEDVDKLQYLKL---VI 361

  Fly   384 LESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDT 446
            .|::|.....||........|:::.||.||  ...|.|:|  |:..:|.|||.||||.|.||||.
plant   362 KETLRLHPPAPLLLPRETMADIKIQGYDIP--RKTILLVNAWSIGRNPELWENPEEFNPERFIDC 424

  Fly   447 EGKVRKPEY-FIPFGVGRRMCLGDV--LARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATI 508
            ....:...: .:|||.||::|.|..  :|.:||.|.  :.::.||..|.|......::....|||
plant   425 PMDYKGNSFEMLPFGSGRKICPGIAFGIATVELGLL--NLLYYFDWRLAEEDKDIDMEEAGDATI 487

  Fly   509 TPESFKVCLKRRPLGPTAADPHH 531
            ..   ||.|:..|:      .||
plant   488 VK---KVPLELVPI------IHH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	131/498 (26%)
CYP71B3	NP_189253.1	p450	1..500	CDD:386267	139/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.900