DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and C4H

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_180607.1	Gene:	C4H / 817599	AraportID:	AT2G30490	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	233/506 - (46%)	Gaps:	75/506 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELR----KLPPGPWGLPVIGYLLFMGSE-KHTRFMELAKQYG 85
            |:.||:.:: |.|::.       :||    ||||||..:|:.|..|.:|.: .|...::.||::|
plant    10 LIAVFVAVI-LATVIS-------KLRGKKLKLPPGPIPIPIFGNWLQVGDDLNHRNLVDYAKKFG 66

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNGYG---IINSTGKLWKDQRR 145
            .||..|:|.:..||:|...:.:|....:  ||..|..........|.|   :....|:.|:..||
plant    67 DLFLLRMGQRNLVVVSSPDLTKEVLLTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRR 131

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSP-----------VISVAV 199
            .:       .:.:..| |...|.|   |..||..   ||..:.|..:|           .:.:.:
plant   132 IM-------TVPFFTN-KVVQQNR---EGWEFEA---ASVVEDVKKNPDSATKGIVLRKRLQLMM 182

  Fly   200 SNVICSLMMSTRF-SIDDPKFRRFNFLIEEGMRLFG--EIHTVDYIPTMQCFPSISTAKNKIAQN 261
            .|.:..:|...|| |.|||.|.|...|..|..||..  |.:..|:||.::.|   .....||.|:
plant   183 YNNMFRIMFDRRFESEDDPLFLRLKALNGERSRLAQSFEYNYGDFIPILRPF---LRGYLKICQD 244

  Fly   262 RAE--MQRFYQDVIDDHKR--SFDPNNIRDL---VDFYLCEIEKAKAEGTDAELFDGKNHEEQLV 319
            ..:  :..|.:..:|:.|:  |..|.....|   :| ::.|.|:           .|:.:|:.::
plant   245 VKDRRIALFKKYFVDERKQIASSKPTGSEGLKCAID-HILEAEQ-----------KGEINEDNVL 297

  Fly   320 QVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTIL 384
            .::.::..|.:||...::.|....::.:|:...::::|||.|:|.....|..||..||..::.:.
plant   298 YIVENINVAAIETTLWSIEWGIAELVNHPEIQSKLRNELDTVLGPGVQVTEPDLHKLPYLQAVVK 362

  Fly   385 ESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINS--VHMDPNLWEKPEEFRPSRFIDTE 447
            |::|....:||...|....|.:|.||.|||.|.:  |:|:  :..:||.|:|||||||.||.:.|
plant   363 ETLRLRMAIPLLVPHMNLHDAKLAGYDIPAESKI--LVNAWWLANNPNSWKKPEEFRPERFFEEE 425

  Fly   448 GKVR---KPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQ 495
            ..|.   ....::|||||||.|.|.:||...|.:.....:..|::..|.||
plant   426 SHVEANGNDFRYVPFGVGRRSCPGIILALPILGITIGRMVQNFELLPPPGQ 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	133/474 (28%)
C4H	NP_180607.1	PLN02394	3..505	CDD:215221	142/506 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810