DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2ad6

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001076405.1	Gene:	cyp2ad6 / 799957	ZFINID:	ZDB-GENE-041001-157	Length:	492	Species:	Danio rerio

Alignment Length:	498	Identity:	160/498 - (32%)
Similarity:	250/498 - (50%)	Gaps:	27/498 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRLGS 94
            :|.|...:.||..|:|| :.....|||||.||::|.:  .....:....:|.::||::||.|:||
Zfish    15 WLFLTCFLLLLIDLIRN-KNPANFPPGPWPLPILGNV--FTDVNYKTVDQLIEKYGNIFSVRIGS 76

  Fly    95 QLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQFGM 156
            ...|.:|.:||:::..  :.|.||.||.:|...|| .|.|:..:.|..|:..::|....|:.|
Zfish    77 DKIVYVSGFKMVKDVLITQGENFTDRPVSPLFDTLYKGRGLSFNNGYSWRKHQQFSMSHLKNF-- 139

  Fly   157 TYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRR 221
               |.|::.:::....|.:...|......|:|.|....|:.||:|||..|:...|:...|..|::
Zfish   140 ---GEGRKTLEENNQRECYFLCGAFKEEQGRPFDPLVKINNAVANVIGFLVFGHRYEYSDVNFQK 201

  Fly   222 FNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST----AKNKIAQNRAEMQRFYQDVIDDHKRSFDP 282
            ...:..|.:.|.|.:....|    ..||.|..    ....|..|..::..|.::.|:.||..:|.
Zfish   202 RLQMSAESVFLTGSVWNQLY----DAFPGIMKWVPGPHQTIISNYQKLANFLEEKIEQHKPDWDI 262

  Fly   283 NNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRN 347
            :|.||.:|.||.|.||.|.: |:|....|     .||..::|||..|.||...||.|..:|:::.
Zfish   263 SNPRDYIDAYLTEAEKKKND-TEAGFTVG-----SLVWSMVDLFEGGTETTTNTLRWALLFLIKY 321

  Fly   348 PKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTI 412
            |...::||.|:|:|:| .|||::.|...:....:.|.|.:||:::|||.......:|..|.||.|
Zfish   322 PDIQKKVQAEIDEVIG-SRLPSMSDKANMHYLNAFIHEVLRRANLVPLNMARVAKKDTTLGGYFI 385

  Fly   413 PAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELF 477
            ..|:.:|..:.||..|...||.|:.|.|..|:|:||...:...|..|..|:|.|.|:.||.:|||
Zfish   386 TKGTVMITNLTSVLYDKQEWETPDAFNPKHFLDSEGHFCRRNAFFAFSAGKRQCPGEYLAHLELF 450

  Fly   478 LFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            :|....:..|..:.|:|:. |||...||.|..|..:|:|...|
Zfish   451 IFLTILLQTFSFSPPDGEE-PSLDSQVGFTQAPLPYKICAHPR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/469 (32%)
cyp2ad6	NP_001076405.1	p450	38..488	CDD:278495	151/468 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820