DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2j20

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	517	Identity:	179/517 - (34%)
Similarity:	272/517 - (52%)	Gaps:	48/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFST 90
            :::|   :.:..||...::| :..:..|||||.||:||.:..:...| |.:..|.|::||.:||.
Zfish    15 ILIF---VCVFLLLSDFIKN-KTPKNFPPGPWSLPIIGDIHHIDPSKLHLQLSEFAEKYGKIFSL 75

  Fly    91 RLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKLR 152
            ||.....||::.|.:::|.:.:|  ....|...| |...:...|::.|:|..||.||||....||
Zfish    76 RLFGPRIVVLNGYNLVKEVYTQEGDNLADRAILPLFHDIIGDKGLVASSGYKWKQQRRFALSTLR 140

  Fly   153 QFGMTYMGNGKQQMQKRIMTE---VHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .||:     ||:.::..|..|   ::|.|.:   ..|||.|...:::.|||||||:|:...||..
Zfish   141 NFGL-----GKKNLEPSINLESGFLNEAISN---EQGQPFDPRLLLNNAVSNVICALVFGNRFDY 197

  Fly   215 DDPKFRRFNFLIEEGMRLFGEI--HTVDYIP-TMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH 276
            .|.||:.....|.|.:.|.|.|  ...:.:| .|:..|.   ...:|.....::..|..:.:::|
Zfish   198 SDHKFQTLLKNINETVHLEGGICAQLYNMLPWLMRLLPG---PHKRIIALWGKLIEFVGEKVNEH 259

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAK---AEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            |...||.|.||.:|.:|.|:||.|   |.|.|.         |.|....:|||.||.||..|||.
Zfish   260 KVDHDPLNPRDYIDCFLDEMEKHKDDTAAGFDV---------ENLCICTLDLFVAGTETTSTTLY 315

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            |..::|::.|:...:||.|:|.:||..|.|::.|...:|.|.:.|.|..|..:|:|:....:.:.
Zfish   316 WGLLYMMKYPEIQAKVQQEIDVIVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINLARTTSE 380

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            |.::..|:||.|:.|...:.||..|.:.||.|..|.|..|:|.|||.|:.:.|:||.:|:|:|||
Zfish   381 DTQIEKYSIPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCLG 445

  Fly   469 DVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPTAADPH 530
            :.||||||||||:|.:..|..:.|.|.. |||..|:|||..|:.:|:|          |.||
Zfish   446 EQLARMELFLFFSSLLQRFTFSPPAGVE-PSLDYNLGATHCPQPYKLC----------AVPH 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	171/475 (36%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	171/474 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720