DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp17a2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001099140.1	Gene:	cyp17a2 / 796487	ZFINID:	ZDB-GENE-100822-1	Length:	495	Species:	Danio rerio

Alignment Length:	509	Identity:	168/509 - (33%)
Similarity:	252/509 - (49%)	Gaps:	49/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ALVTLLQWLVRNYRE--------LRKLPPGPWGLPVIGYLLFMGSE--KHTRFMELAKQYGSLFS 89
            ||:.||..|||...|        ...||    .||::|.||.:.|.  .|..|.:|:.|||.||.
Zfish    12 ALLLLLLLLVRRLLEGVGSSSVSFPCLP----RLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFG 72

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPD--TPFMQTLNGYGI-INSTGKLWKDQRRFLHD 149
            ...|..||:|:|:..::||..  |..||.|||.  |..:.|..|..| ......|||:.||.:|.
Zfish    73 LYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLVHS 137

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
                 ..|..|.|..::|..:..........|.|..||..|:|.|:..||:||||.|:.|:.:..
Zfish   138 -----SFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSYQP 197

  Fly   215 DDPKFR---RFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEM-----QRFYQD 271
            .||:.:   ::|..|.:.:...|   .||..|.::.||      ||..:...|.     |..|:.
Zfish   198 SDPELQTVIQYNDGIVQTIARGG---LVDIFPWLRIFP------NKDLKRLKECVSIRDQLLYKK 253

  Fly   272 VIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            :: :||:|..|...|||:|..|...::......|..       |:.::....:.|.||:||..||
Zfish   254 LL-EHKKSLTPGEPRDLLDALLIGQQRGSGGADDIT-------EDHVLMTAAEAFGAGVETTSTT 310

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |||...|:|.:|:...|||.|||:.||..|.|.:.|..:||:.::.:.|.||...:.|:...|..
Zfish   311 LLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVA 375

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            .:|..|.|:::|.|:.|:..:.::|.||..|::||:|.|.||::..||.:....|:|||.|.|:|
Zfish   376 MQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVC 440

  Fly   467 LGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            :|:.|||:|||||.:..:..|..:.|....||.|:|..|..:.||.:.|.:..|
Zfish   441 VGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVVLQPERYTVTVTPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	158/477 (33%)
cyp17a2	NP_001099140.1	p450	55..491	CDD:278495	151/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810