Protein Alignment Cyp18a1 and cyp21a2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_021330030.1
• Gene: cyp21a2 / 793249
• ZFINID: ZDB-GENE-070103-6
• Length: 522
• Species: Danio rerio
• Alignment Length: 478
• Identity: 132/478 - (27%)
• Similarity: 222/478 - (46%)
• Gaps: 45/478 - (9%)

  Fly    56 GPWGLPVIGYLLFMGSEKH--TRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFT 116
            ||..||::|.:|.: ::.|  .....|||.||:::....||...||:::.::|||...::  :|.
Zfish    65 GPRSLPLLGNMLDL-AQDHLPIHLTALAKCYGNIYRLNCGSTTMVVLNNSEIIREALVKKWSDFA 128

  Fly   117 GRPDTPFMQTLNGYGIINSTGKL---WKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFI 178
            |||.:.....::..|...|.|..   ||..||..|..|::.....:.:..::..:.:...:.::
Zfish   129 GRPHSYTGDIVSRGGRTISLGDFSEEWKAHRRVTHSALQRCTTDSLHSVIEKQAQHLCQVLRDY- 192

  Fly   179 GHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGE--IHTVDY 241
                  .|:.||:|...:||.||||.:|..|..:.....:.::....:.|.:.|:|.  |..:|.
Zfish   193 ------SGKAVDLSEDFTVASSNVITTLTFSKAYDKSSAELQKLQECLNEIVSLWGSPWISALDS 251

  Fly   242 IPTMQCFPS--ISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRD---LVDFYLCEIEKAKA 301
            .|.::.||:  .|....::|:.        .::|..|...|..:..::   |....|..:|..:.
Zfish   252 FPLLRKFPNPPFSRLMKEVARR--------DELIGKHIEEFKKSEHKEGGTLTSSLLKCLEPQQG 308

  Fly   302 EGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVG-RH 365
            ......|.|...|     ...:||...|.|||...|.|...|:|..|:...:|.:||..::. ||
Zfish   309 AANHTTLTDTHVH-----MTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCMLDVRH 368

  Fly   366 RLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPN 430
              |...|...||...:.|.|.:|...:.|||..|...|:..:.|:.||..:.:||.:...|.||.
Zfish   369 --PQYSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNLYGAHHDPE 431

  Fly   431 LWEKPEEFRPSRFID-TEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALP-- 492
            :|:.|..|:|.||:: ..|.:|.   .||||.|.|:|||:.:|:||:|||.|..:..|.. ||
Zfish   432 VWDDPYSFKPERFLEGGGGSLRS---LIPFGGGARLCLGEAVAKMEMFLFTAYLLREFKF-LPAS 492

  Fly   493 EGQPLPSLKGNVGATITPESFKV 515
            :.:|||.|:|.....:..:.:.|
Zfish   493 KEEPLPELRGVASVVLKVKPYTV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	120/445 (27%)
cyp21a2	XP_021330030.1	cytochrome_P450	94..516	CDD:477761	122/448 (27%)