DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and si:dkey-286h2.3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001073322.1	Gene:	si:dkey-286h2.3 / 790965	ZFINID:	ZDB-GENE-161014-2	Length:	496	Species:	Danio rerio

Alignment Length:	508	Identity:	155/508 - (30%)
Similarity:	256/508 - (50%)	Gaps:	26/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFME-LAKQYGSLFST 90
            ::..|.||.|...|.:|....|..|..||||..:|:.|.||.:......:.:: .|:.|||::..
Zfish     1 MLTALVLLCLGAFLLYLQLRIRRPRNFPPGPAPVPIFGNLLQLNHINPIKDLDKFAQHYGSIYGI 65

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFM-QTLNGYGIINST-GKLWKDQRRFLHDKL 151
            .:||:..||::..|||:|..  :..||.||.:...: ......|:|.:. |:.|::.|||....|
Zfish    66 YIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVSHVTRSKGVIMADYGESWREHRRFALTTL 130

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.||:     ||:.|::||:.||......|..|.|:|:|...:...|.||:|.|::..:||...|
Zfish   131 RNFGL-----GKKSMEQRILEEVKHICLLLEESAGKPIDPQHLYHQAASNIIASIIFRSRFDYQD 190

  Fly   217 PKFRRFNFLIEEGMRL----FGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHK 277
            ..|:.....:|:..::    :..::.:  .|.::.||   ...:|..|...::......|:::||
Zfish   191 EYFQTLITTMEKLTKIAIGPWAMLYEI--APVLRIFP---LPFHKAFQYFEQITNHVLKVVEEHK 250

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINV 342
            .|......|||:|.||.|:.:...:.|   .||    |.|:|.::.|||.||.||...||..:.:
Zfish   251 TSRVAGEPRDLIDCYLEEMNRRSDKHT---TFD----ESQMVTLLFDLFIAGTETTSNTLRTLTL 308

  Fly   343 FMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVEL 407
            :::.......:.|.|:|:|:|.....|.||...:...::.|.|..|.:.||||:..|:...|.:|
Zfish   309 YLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIVPLSMFHTARTDTQL 373

  Fly   408 NGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLA 472
            .||:||.|:.:||.::|...:...|:.|.||.|..|::.:|:..|.:.|:||..|.|:|||:.||
Zfish   374 RGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGENLA 438

  Fly   473 RMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPT 525
            ||||||...:.:..|.:..|:....|......|.|.:.:.:.:.:|.|..|.|
Zfish   439 RMELFLILVTVLRKFRLVWPKDAEEPDFTYIYGGTQSLKPYPMIVKLRTPGET 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	143/471 (30%)
si:dkey-286h2.3	NP_001073322.1	p450	28..485	CDD:278495	143/473 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.800