DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x9

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001070921.1	Gene:	cyp2x9 / 768288	ZFINID:	ZDB-GENE-061027-109	Length:	491	Species:	Danio rerio

Alignment Length:	499	Identity:	160/499 - (32%)
Similarity:	254/499 - (50%)	Gaps:	18/499 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFST 90
            ::.||.|:.:..:|.:|.......:..||||..||:.|.||.:......: |..||.:||:::|.
Zfish     1 MLGFLILVWICIVLLFLFIQIPRPKNFPPGPRPLPLFGNLLELNINNPLKDFERLANRYGNIYSL 65

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRP-DTPFMQTLNGYGIINST-GKLWKDQRRFLHDKL 151
            ..||:..||::.::.::|..  :..:|.||| |....:...|.|:|.|. |..||:.|||....|
Zfish    66 YFGSKPWVVLNGFEALKEALVTKAVDFAGRPQDLMVNRVTKGGGVILSDYGPSWKEHRRFALMTL 130

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.||:     |||.|::||:.||...|..|....|...|...:...|.||:||.::..:|:..||
Zfish   131 RNFGL-----GKQSMEERILGEVSHIIDKLEKRVGTAFDPQTMFHNAASNIICIVLFGSRYDYDD 190

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFD 281
            ...:.|..|..|..::......:.| .|...|..:.....|...|.::.:.....::.:||:::.
Zfish   191 EFLKLFIHLYTENAKIANGPWAMIY-DTFPMFRYLPLPFRKAFANASKARELSTQLVKEHKKTWV 254

  Fly   282 PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLR 346
            |...||.:|.||.|::|   .|.|...|.    |.||:..::||..||.:|...|||...::::.
Zfish   255 PGEPRDFIDCYLDELDK---RGNDGSSFS----EAQLILYVLDLHFAGTDTTSNTLLTGFLYLMT 312

  Fly   347 NPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYT 411
            :|:...:.|.|:|.|:......:.||...:|.|::...|..|.::.|||:..|..|:|.||.||.
Zfish   313 HPEVQAKCQQEIDDVLEDKDQASYEDRHSMPYTQAVTHEVQRVANTVPLSVFHCTTKDTELMGYN 377

  Fly   412 IPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMEL 476
            ||.|:.|||.:.|...:...|:.|.||.|:.|::.:|:..|||.|:||..|.|:|||:.||||||
Zfish   378 IPKGTFVIPNLGSALKEEGQWKFPHEFNPANFLNEQGEFEKPEAFVPFSAGPRVCLGEGLARMEL 442

  Fly   477 FLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            ||...:.:..|....|.....|......|.|:||:.:::.:|||
Zfish   443 FLVMVTLLRRFQFVWPNDAGKPDYTPVYGVTLTPQPYRMHIKRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	152/467 (33%)
cyp2x9	NP_001070921.1	p450	28..479	CDD:278495	152/463 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720