Protein Alignment Cyp18a1 and Cyp2d26

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_083838.1
• Gene: Cyp2d26 / 76279
• MGIID: 1923529
• Length: 500
• Species: Mus musculus
• Alignment Length: 532
• Identity: 186/532 - (34%)
• Similarity: 272/532 - (51%)
• Gaps: 69/532 - (12%)

  Fly    21 GDAQHLLMVFLGL-LALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQ 83
            ||....:::|..: |.||.|:.   |..|.....||||...|.:|.||.:..|. ...|.:|..:
Mouse     6 GDDLWAVVIFTAIFLLLVDLVH---RRQRWTACYPPGPVPFPGLGNLLQVDFENIPYSFYKLQNR 67

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG------IINSTGKLW 140
            ||::||.::..:..||::..|.:||..  ..|:.:.||..|....: |||      |:...|..|
Mouse    68 YGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHI-GYGHKSKGVILAPYGPEW 131

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDG------QPVDMSPVISVAV 199
            ::||||....||.||:     ||:.:::.:..|.    |||  .|.      .|.:.||::|.||
Mouse   132 REQRRFSVSTLRDFGL-----GKKSLEQWVTEEA----GHL--CDAFTKEAEHPFNPSPLLSKAV 185

  Fly   200 SNVICSLMMSTRFSIDDPKFRRFNFLIEEGM----RLFGEIHTVDYIPTM--------QCFPSIS 252
            ||||.||:.:.||..:||.|.|....::|.:    ...||:  ::.||.:        :.||.::
Mouse   186 SNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEV--LNAIPMLLHIPGLPDKAFPKLN 248

  Fly   253 T---AKNKIAQNRAEMQRFYQDVIDDHKRSFDP-NNIRDLVDFYLCEIEKAKAEGTDAELFDGKN 313
            :   ..||              ::.:|..::|| ...|||.|.:|.|:||||  |.....|:.||
Mouse   249 SFIALVNK--------------MLIEHDSTWDPAQPPRDLTDAFLAEVEKAK--GNPESSFNDKN 297

  Fly   314 HEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPI 378
                |..|:||||.|||.|..|||.|..:.|:.:|...|||..|:|:|:|..|.|.:.|...:|.
Mouse   298 ----LRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPY 358

  Fly   379 TESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRF 443
            |.:.|.|..|.:.|||....|..:||::...:.||.|:.:||.::||..|..:||||..|.|..|
Mouse   359 TNAVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYPEHF 423

  Fly   444 IDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATI 508
            :|.:|...|.|.|:||..|||.|||:.||||||||||...:..|..::|:|||.||..|.....:
Mouse   424 LDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSDYGIYTMPV 488

  Fly   509 TPESFKVCLKRR 520
            |||.:::|...|
Mouse   489 TPEPYQLCAVAR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	163/459 (36%)
Cyp2d26	NP_083838.1	CYP2D	68..495	CDD:410756	164/460 (36%)