DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2k17

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001036243.2	Gene:	cyp2k17 / 735313	ZFINID:	ZDB-GENE-070424-41	Length:	503	Species:	Danio rerio

Alignment Length:	508	Identity:	182/508 - (35%)
Similarity:	271/508 - (53%)	Gaps:	39/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LGLLALVTLLQWLVRN--YRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRL 92
            ||.|.|:.:...|.|:  :::.||.||||..:|::|.||.:. |.......||:|.||:::...|
Zfish    16 LGTLLLLLVFYRLSRDSEFQKKRKDPPGPKPIPLLGNLLTLDLSRPFDSLCELSKTYGNVYQVFL 80

  Fly    93 GSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQF 154
            |.:..||:..:|.::|....  :||..|..||..:.| |.:||:.|.|:.||:.|||....||.|
Zfish    81 GPKKVVVLIGHKTVKEALVNFADEFGERDITPIFRILANDHGILFSNGESWKEMRRFAISNLRDF 145

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            ||     ||:..:::|:.|:|...|.....:|:|.|.:..::.||||:|.|::..:||...||:|
Zfish   146 GM-----GKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRF 205

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIPTMQCFP-------SISTAKNKIAQNRAEMQRF---YQDVID 274
            ........|.:|:.|....:.|    ..||       |..|....:.:||||..:.   .|:.::
Zfish   206 TEMVDRANENIRVSGSASMMLY----NIFPWLGPFLNSKRTVVRNMLKNRAEFMKLITGLQETLN 266

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            .|.|       |..||.:|...:..:..|.....|    |.|.|:..:.:||:||.:|..|||.|
Zfish   267 IHDR-------RGFVDSFLIRKQSDEQLGKKDTYF----HAENLLMTVGNLFAAGTDTTGTTLRW 320

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRD 404
            ..:.|.:.|:...|||:|:|:|:| .|.|.:||.:.||.|::.|.|..|.::|||:...|..:.|
Zfish   321 GLMLMAKYPQIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPMNLPHVTSCD 384

  Fly   405 VELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGD 469
            |..|||.|..|:.||||:.||..|.:.||||..|.|..|:|.:|:..|.:.|:||..|||:|||:
Zfish   385 VTFNGYFIKKGTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFIKRDAFMPFSAGRRVCLGE 449

  Fly   470 VLARMELFLFFASFMHCFDIALPEG--QPLPSLKGNVGATITPESFKVCLKRR 520
            .||||||||||||.:..:....|.|  :....|||.||.|:.|...|:|..:|
Zfish   450 SLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVGVTLNPSPHKLCAIKR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	172/478 (36%)
cyp2k17	NP_001036243.2	p450	41..498	CDD:278495	172/477 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2702
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.870