Protein Alignment Cyp18a1 and Cyp2c65

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_082467.2
• Gene: Cyp2c65 / 72303
• MGIID: 1919553
• Length: 490
• Species: Mus musculus
• Alignment Length: 512
• Identity: 171/512 - (33%)
• Similarity: 266/512 - (51%)
• Gaps: 48/512 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFM-ELAKQYGSLFS 89
            :|.||||||....||..|.|...:.|.|||||..||:||.:|.:..:..::.: ..:|.||.:|:
Mouse     2 VLGVFLGLLLTCLLLLSLWRQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRNFSKVYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKL 151
            ..||....||:..|:.::|.|  ..|||.||...| |.:.....|::.|:|:.||:.|||....|
Mouse    67 LYLGRNPAVVLHGYEAVKEAFTDHGEEFAGRGVFPVFDKFKKNCGVVFSSGRTWKEMRRFSLMTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     |::.::.||..|....:..|..:.|:|.|.:.::..|..|||||::...||...|
Mouse   132 RNFGM-----GRRSIEDRIQEEARCLVDELRKTKGEPCDPTFILGCAPCNVICSIVFQNRFDYKD 191

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSI----STAKNKIAQNRAEMQRFYQDVIDDHK 277
            .:|..|..::.|.:    ||.:..:|.....||::    .....|:.:|.|..:.::...:..|:
Mouse   192 QEFLTFLDILNENV----EILSSPWIQICNNFPAVIDYLPGRHRKLHKNFAFAEHYFLSKVKQHQ 252

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE-------EQLVQVIIDLFSAGMETIKT 335
            .|.|.||.||.:|.:|.::|:.|             |.       |.||....|||:||.||..|
Mouse   253 ESLDINNPRDFIDCFLIKMEQEK-------------HNPKTEFTCENLVFTASDLFAAGTETTST 304

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||.:..:.:|:.|:...:||:|:|.|:||||.|.::|...:|.|::.:.|..|...::|.:..|:
Mouse   305 TLRYSLLLLLKYPEVTAKVQEEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHA 369

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .||||:...|.||.|:.||..:.||..|...:..||:|.||.|:|..||.:|.:||.||..|:|:
Mouse   370 VTRDVKFREYLIPKGTTVIASLTSVLYDDKEFPNPEKFDPSHFLDERGKFKKSDYFFPFSTGKRI 434

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALP------EGQPLPSLKGNVGATITPESFKVC 516
            |:|:.|||.|||||..:.:..|::..|      :..|:.:     |....|..|::|
Mouse   435 CVGEGLARAELFLFLTTILQNFNLKSPVDLKDLDTTPVAN-----GFASVPPKFQIC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	146/449 (33%)
Cyp2c65	NP_082467.2	CYP2C-like	61..485	CDD:410758	147/450 (33%)