DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b15

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001129140.1	Gene:	Cyp2b15 / 685222	RGDID:	1596474	Length:	495	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	162/509 - (31%)
Similarity:	263/509 - (51%)	Gaps:	32/509 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LGLLALVT-----LLQWLVRNYRELR-KLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLF 88
            ||:|.|:|     ||....:|..:.. .|||||..||.:|.||.|......| ||:|.::||.:|
  Rat     3 LGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVF 67

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDK 150
            :..||.:..|::.....|||..  :.|.|:||.....:. .:.|||:|.:.|:.||..|||....
  Rat    68 TVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGERWKILRRFSLVT 132

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            :|.|||     ||:.:::||..|....:..|....|..::.:.:.....:|:|||::...||...
  Rat   133 MRNFGM-----GKRSVEERIKEEAQCLVEELKKYKGALLNPTSIFQSIAANIICSIVFGERFDYK 192

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVD---YIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHK 277
            |.:|.|...||.:...|.|.:.:..   :...::.||.:   ..:|::|..|:..:....::.|:
  Rat   193 DHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGV---HKQISKNLQEILNYIDHSVEKHR 254

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINV 342
            .:.|||..||.::.||..:||.|:.      ...:.|.:.||..::.||..|.||..|||.:..:
  Rat   255 ATLDPNTPRDFINTYLLRMEKEKSN------HHTEFHHQNLVISVLSLFFTGTETTSTTLRYSFL 313

  Fly   343 FMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVEL 407
            .||:.|....:||.|:|||:|.|||||::|...:|.|::.|.|..|.:.::|:...|..|.|...
  Rat   314 IMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMF 378

  Fly   408 NGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLA 472
            .||.:|..:.|.|:::|...||..::.|:.|.|..|:|..|.::|.|.|:||..|:|:|||:.:|
  Rat   379 LGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTLKKSEAFLPFSTGKRICLGEGIA 443

  Fly   473 RMELFLFFASFMHCFDIA---LPEGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            :.|||:||.:.:..|.:|   .||...|..:  |.|.:..|..:::....|.:|
  Rat   444 QNELFIFFTAILQNFSLASPVAPEDIDLSPI--NSGISKIPSPYQIHFLSRCVG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/472 (32%)
Cyp2b15	NP_001129140.1	p450	32..487	CDD:278495	151/470 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720