DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and Cyp2ab1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_017453675.1	Gene:	Cyp2ab1 / 679979	RGDID:	1586963	Length:	494	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	147/449 - (32%)
Similarity:	222/449 - (49%)	Gaps:	31/449 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNG-YGIINSTGKLW 140
            :||:.:|::|:..|||...||::.::.::|..  ..|:|:|||.|||.:.|.| .|:|.|.|..|
  Rat    53 QLAQTHGNVFTVWLGSTPIVVLNGFRAVKEALVSNSEQFSGRPLTPFFRDLFGEKGVICSNGLTW 117

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICS 205
            :.||||....||:.|:     |||.::.::..|..|.....|...|:..|....|..:.:.||.:
  Rat   118 RQQRRFCLTTLRELGL-----GKQALELQLQHEAAELAEVFHQEQGRAFDPQVPIIRSTTRVIGA 177

  Fly   206 LMMSTRFSIDDPKFRRFNFLIEEGM--------RLFGEIHTVDYIPTMQCFPSISTAKNKIAQNR 262
            |:....|..::|.|......|..|:        ||:      |..|....:  :|....||.|..
  Rat   178 LVFGHHFLSEEPIFLELIRAINLGLAFASTTWRRLY------DMFPWALRY--LSGPHQKIFQYH 234

  Fly   263 AEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFS 327
            ..::.|....|..||.. .|...:|.:..||.:|.||..:  ....|.    ||.|:||:||||.
  Rat   235 EAVRGFIHHEIIRHKLR-TPEAPKDFISCYLSQITKAMDD--PVSTFS----EENLIQVVIDLFL 292

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            .|.:|..|||.|..::::.:.....|||.|||:|:|..:....||.:.||.|.:.:.|..|.||:
  Rat   293 GGTDTTATTLHWAIIYLVHHRAIQERVQQELDEVLGTAQAVCYEDRERLPYTRAVLHEVQRLSSV 357

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFI 457
            |.:...........::||.:..|:.::|.:.||..||..||.|.:|.|..|:|.:|.....|.|:
  Rat   358 VAVGAVRQCVTPTWMHGYYVSKGTIILPNLASVLCDPECWETPHQFNPGHFLDKDGDFVTNEAFL 422

  Fly   458 PFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||..|.|:|.|:.||||||||.||:.:..|...||||.....|:...|.|:.|:..|:|
  Rat   423 PFSAGHRVCPGEQLARMELFLMFATLLRTFRFQLPEGSQGLRLEYVFGGTLQPQPQKIC 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	147/449 (33%)
Cyp2ab1	XP_017453675.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910