DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2j4

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_075414.2	Gene:	Cyp2j4 / 65210	RGDID:	620007	Length:	501	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	166/510 - (32%)
Similarity:	269/510 - (52%)	Gaps:	44/510 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AQHLLMVFLGLLALVTLLQWLVRNY---RELRKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQ 83
            |.||..:   |:|.:|.|  |:.:|   |..:..||||||||.:|.:..:. .:.|.......|:
  Rat    15 ALHLRTL---LVAALTFL--LLADYFKTRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPFVKK 74

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECFR--REEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRR 145
            ||::||..||...:||::...:|:|.|.  .:....||.:...:.: |..|:|.|:|:.||:|||
  Rat    75 YGNIFSLNLGDITSVVITGLPLIKETFTHIEQNILNRPLSVMQERITNKNGLIFSSGQTWKEQRR 139

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            |....||.||:     ||:.:::|:..|.|..:..:....|:|.:....|:.||||:|||:....
  Rat   140 FALMTLRNFGL-----GKKSLEQRMQEEAHYLVEAIREEKGKPFNPHFSINNAVSNIICSVTFGE 199

  Fly   211 RFSIDDPKFRRFNFLIEEGMRL----FGEIHTV-----DYIPTMQCFPSISTAKNKIAQNRAEMQ 266
            ||...|.:|:....|::|.|.|    ..:::.:     .|||         .:...:.:|..:::
  Rat   200 RFEYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIP---------GSHQTVFRNWEKLK 255

  Fly   267 RFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGME 331
            .|...:||||::.::|...||.:|.:|.|:.|...:.|..       :||.|:...:|||.||.|
  Rat   256 LFVSSMIDDHRKDWNPEEPRDFIDAFLKEMSKYPEKTTSF-------NEENLICSTLDLFFAGTE 313

  Fly   332 TIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLA 396
            |..|||.|..::|....:...:||.|:|:|:|:.|..::.|.:.:|.|.:.|.|..|..:|:||.
  Rat   314 TTSTTLRWALLYMALYAEVQEKVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLN 378

  Fly   397 TTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGV 461
            .......|..|||:.:|.|:.|:..:.::|.||..|..|:.|.|..|:: .|:.:|.|.|:||.:
  Rat   379 VPREVAMDTTLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLE-NGQFKKRESFLPFSM 442

  Fly   462 GRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|.|||:.|||.|||:||.|.|..|....|..:.| |||...|.|::|.:.::|
  Rat   443 GKRACLGEQLARSELFIFFTSLMQKFTFKPPTNEKL-SLKFRNGLTLSPVTHRIC 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	156/476 (33%)
Cyp2j4	NP_075414.2	p450	44..496	CDD:278495	155/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	304	1.000	Domainoid score	I1330
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720