DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2ae1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_009295394.1	Gene:	cyp2ae1 / 572114	ZFINID:	ZDB-GENE-090312-107	Length:	497	Species:	Danio rerio

Alignment Length:	494	Identity:	177/494 - (35%)
Similarity:	274/494 - (55%)	Gaps:	31/494 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNYREL--RKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRLGS 94
            |:.|..||  ||:::|::  :.:||||:.||.:|.|..:| |:....|..:|::||.:.:..||:
Zfish    19 LIFLCVLL--LVKHFRDVYSKNMPPGPFPLPFVGNLTNIGFSDPLGSFQRIAEKYGDVCTLYLGT 81

  Fly    95 QLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQFGM 156
            :..::|:.|..::|.|  :.:.||.||..|.:..| ||.|:|.|:|.:|:.||||....|:.||:
Zfish    82 KPCILMTGYDTLKEAFVEQADIFTDRPYFPIVDKLGNGKGLIMSSGHMWRQQRRFALATLKYFGV 146

  Fly   157 TYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRR 221
                 ||:.::..|:.|.......|.|..|.|.|...:::.||||:||.|:...||..||.:|..
Zfish   147 -----GKKTLENAILQECRFLCDSLQAERGLPFDPQHLVTNAVSNIICGLVFGHRFEYDDHQFHL 206

  Fly   222 FNFLIEEGMRL----FGEIHTVDYIPTMQCFPSISTAKNKIA-QNRAEMQRFYQDVIDDHKRSFD 281
            ....|...::|    :|.::  :..||:.   |:...|::.| .:.:::|.|.::.|..|::..:
Zfish   207 MQTYINNILQLPISNWGRLY--NEFPTLM---SLLPGKHQTAFASMSKLQPFLKEEITKHQQDRE 266

  Fly   282 PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLR 346
            |::.||.:|.||.||||.|  .:|||.     .||.|:..::|||.||.||...||.|...||::
Zfish   267 PSSPRDYIDCYLEEIEKCK--DSDAEF-----TEENLMFCVVDLFGAGTETTSNTLRWALAFMVK 324

  Fly   347 NPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYT 411
            .|....:||.|:|||:|:.|.|.::|...||.|.:.|.|..|.::||.........:|..:.|..
Zfish   325 YPDVQEKVQSEIDQVIGQTRQPLMDDRTNLPYTYAVIHEIQRFANIVTFTPPRVANKDTTVGGQL 389

  Fly   412 IPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMEL 476
            ||.|..|:|::..:.:|...:..|.:|.|..|:|..||..|.|.||||.:|:|||.|:.||||||
Zfish   390 IPKGVIVLPMLKPILLDKKEYSTPYDFNPDHFLDQNGKFLKKENFIPFSIGKRMCPGEQLARMEL 454

  Fly   477 FLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKV 515
            ||||.|.|..|.....|||.| ||||....:..|:.|::
Zfish   455 FLFFISLMQHFTFLPVEGQKL-SLKGTTSVSSAPQPFQI 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	170/471 (36%)
cyp2ae1	XP_009295394.1	p450	40..492	CDD:306555	170/469 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720