Protein Alignment Cyp18a1 and cyp2aa1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001020728.2
• Gene: cyp2aa1 / 572000
• ZFINID: ZDB-GENE-070424-33
• Length: 498
• Species: Danio rerio
• Alignment Length: 505
• Identity: 165/505 - (32%)
• Similarity: 273/505 - (54%)
• Gaps: 37/505 - (7%)

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYL-LFMGSEKHTRFMELAKQYGSLFST 90
            |.:||||:.||....:.:.:|:  .:.||||..||.:|.| .|:.|.  ..|:....|||.:.:.
Zfish    15 LTLFLGLIFLVLFEIFRIHSYK--GRFPPGPTPLPFVGNLPHFLKSP--MEFIRFMPQYGEMTTI 75

  Fly    91 RLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTL-NGYGIINST-GKLWKDQRRFLHDKLRQ 153
            ..|.:..::::..::.:|.:.::.|:|||..|....: ||.||:..| ...|:.||||....||.
Zfish    76 FFGRKPVIMLNTIQLAKEAYVQDVFSGRPAIPLFDWITNGLGIVMVTFNNSWRQQRRFALHTLRN 140

  Fly   154 FGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPK 218
            ||:     ||:.::.|::.|....|..:...:|:.::....:..|:||:|||::...||..|:
Zfish   141 FGL-----GKKTVEDRVLEESRYLIAEMLKEEGKSMNPQHALQNAISNIICSIVFGDRFEYDN-- 198

  Fly   219 FRRFNFLIE---EGMRLFGEI--HTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKR 278
             :||.:|::   |.:.|.|..  ...:.:|.::.||.   ...||.||..|:..|.:|...:|::
Zfish   199 -KRFEYLLKTLNENIMLAGSAAGQIFNLVPFIKHFPG---PHQKIKQNADELLGFIRDEAKEHRQ 259

  Fly   279 SFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVF 343
            :.||::.||.:|.||.||||.|:..      |...|||.||....|||.||.:|.:||:.|..:.
Zfish   260 TLDPDSPRDFIDAYLLEIEKQKSSK------DSTFHEENLVVSASDLFLAGTDTTETTIRWGLIN 318

  Fly   344 MLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVP--LATTHSPTRDVE 406
            :::||....|..:|:.:|:|..|||:::|...||.|.:|:.|..|.::|.|  :..|..||:
Zfish   319 LIQNPDVQERCHEEIVRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTK--- 380

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVL 471
            |:||.||.|:.::..:.::..:...|:.|:.|.|..|:|..|...|||.||||.:|.|:|||:.|
Zfish   381 LHGYNIPQGTIILTNLAAIFSNKEHWKHPDAFNPENFLDENGHFSKPESFIPFSLGPRVCLGETL 445

  Fly   472 ARMELFLFFASFMHCFDIAL-PEGQPLPSLKGNVGATITPESFK-VCLKR 519
            ||.|||||..:.:.....:. |:.:|: .:.|.:|...:|::|. ||..|
Zfish   446 ARTELFLFITALLQRIRFSWPPDAKPI-DMDGIMGLVRSPQTFNVVCHSR 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	141/440 (32%)
cyp2aa1	NP_001020728.2	cytochrome_P450	69..489	CDD:477761	142/440 (32%)