DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2ad3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001020725.1	Gene:	cyp2ad3 / 569245	ZFINID:	ZDB-GENE-041001-156	Length:	493	Species:	Danio rerio

Alignment Length:	507	Identity:	177/507 - (34%)
Similarity:	264/507 - (52%)	Gaps:	22/507 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELA 81
            :.::.|.:..:::..|||.||.|::     |......||||..||.:|. :|...:......:||
Zfish     6 IYENFDFKSWILLGFGLLLLVDLIK-----YWNPSSFPPGPRPLPFLGN-VFTEIQDFRNINKLA 64

  Fly    82 KQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQ 143
            :.||::||.||||:..:::|.|||.:|..  :.:.|..||:.| |.:...|.|.|.|.|.||:..
Zfish    65 QVYGTIFSLRLGSEKLIIVSGYKMAKEALVTQNDSFIDRPNVPLFHKVFKGLGTILSNGYLWRMH 129

  Fly   144 RRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMM 208
            |:|....||.||:     |.:.::.:|..|.........|..| |||....::.|:||:|.||:.
Zfish   130 RKFAVSHLRNFGV-----GNESLEVKIQQECIFLCDAFKAEKG-PVDPMVTLNSAISNIISSLIF 188

  Fly   209 STRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVI 273
            ..||...|..::|...|..|.::|.|......|......|..:......|..|..:::.|.:..|
Zfish   189 GQRFDYHDEYYQRILRLDTECIQLAGSPRAQLYNACPWLFEYLPGPHQTIFSNYKKIKDFLRGEI 253

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            ..|:..:||.|.||.:|.||.|:|:.|   :|.|.  |.| .|.||...:||..||.||..|||.
Zfish   254 IKHREDWDPANPRDFIDNYLTEMERKK---SDPEA--GFN-IEGLVVTCLDLIEAGTETATTTLR 312

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            |..:||::.|:...:||.|:|:|:|:.|.|.:.|...:|.||:.|.|..|...:|||.......:
Zfish   313 WGLLFMIKFPEIQEKVQAEIDRVIGQSRQPCLNDRVNMPYTEAVIHEIQRFGDVVPLGFPKRAVK 377

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            |.:|..|.||.|:.:...::||..|||.||.|:.|.|..|:|..|:.||.:.|:||..|:|.|||
Zfish   378 DTQLGKYFIPKGTAITVNLSSVLHDPNEWETPDTFNPGHFLDEIGQFRKRDAFMPFSAGKRACLG 442

  Fly   469 DVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            :.|||.||||:|.|.:..|.|:...|:. |||:|.:..|..|..|.:|:..|
Zfish   443 ENLARQELFLYFTSLLQQFKISKCPGEE-PSLEGEIWFTYAPAPFHICVSSR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	167/465 (36%)
cyp2ad3	NP_001020725.1	p450	38..471	CDD:278495	160/446 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920