Protein Alignment Cyp18a1 and Cyp2d22

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_062797.3
• Gene: Cyp2d22 / 56448
• MGIID: 1929474
• Length: 500
• Species: Mus musculus
• Alignment Length: 497
• Identity: 177/497 - (35%)
• Similarity: 257/497 - (51%)
• Gaps: 34/497 - (6%)

  Fly    34 LALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTRLGSQLT 97
            |.||.|:.|   ..|.....||||...||:|.||.|..:. ...|.:|..:||.|||.:|.|:..
Mouse    20 LILVNLMHW---RQRWTAHYPPGPMPWPVLGNLLHMDFQNMPAGFQKLRGRYGDLFSLQLASESV 81

  Fly    98 VVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG------IINSTGKLWKDQRRFLHDKLRQF 154
            ||::....:||..  ..|:...||...|...| |:|      ::...|..|:.||||....:..|
Mouse    82 VVLNGLTALREALVKHSEDTADRPPLHFNDLL-GFGPRSQGIVLARYGPAWRQQRRFSVSTMHHF 145

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            |:     ||:.:::.:..|............|.|...:.::..||.|||.||:.:.||..|||:|
Mouse   146 GL-----GKKSLEQWVTEEARCLCAAFADHTGHPFSPNTLLDKAVCNVIASLLYACRFEYDDPRF 205

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIPT-MQCFP---SISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .|...|::|.::     ....::|. :..||   .|.....|:...:........:::.:||.::
Mouse   206 IRLLGLLKETLK-----EEAGFLPMFLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTW 265

  Fly   281 DPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            ||.. .|||.|.:|.|:||||  |.....|    ::|.|..|:.|||||||.|..|||.|..:.|
Mouse   266 DPTQPPRDLTDAFLAEVEKAK--GNPESSF----NDENLRTVVGDLFSAGMVTTSTTLSWALMLM 324

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            :.:|...||||.|:|:|:|:.:.|.:.|...:|.|.:.|.|..|.:.|:||...|..:||:||.|
Mouse   325 ILHPDVQRRVQQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQG 389

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            :.||.|:.:|..::|...|..:||||..|.|..|:|.:|...|||.|:||..|||.|||:.||||
Mouse   390 FLIPKGTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARM 454

  Fly   475 ELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||||||...:..|.|::|:|||.||..|...|..||..:::|
Mouse   455 ELFLFFTCLLQRFSISVPDGQPQPSDHGVFRALTTPCPYQLC 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	157/442 (36%)
Cyp2d22	NP_062797.3	CYP2D	68..495	CDD:410756	158/443 (36%)