DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2k8

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001124095.1	Gene:	cyp2k8 / 561462	ZFINID:	ZDB-GENE-080721-19	Length:	507	Species:	Danio rerio

Alignment Length:	489	Identity:	171/489 - (34%)
Similarity:	263/489 - (53%)	Gaps:	21/489 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTRLGSQLTVV 99
            |:.|:.:|:.......:.||||..||::|.|..:..:. |....||:|:||.:|...||.:..||
Zfish    22 LLFLVVYLISISSSSPEDPPGPKPLPLLGNLHTLDLKNLHVSLWELSKKYGPVFKVHLGRKKVVV 86

  Fly   100 MSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGN 161
            ::.||.:::..  :.|||..|..||..|..| |.||:.:.|:.|:..|||....||.|||
Zfish    87 LAGYKTVKQALVNQAEEFGERDITPIFQDCNQGQGIVFANGERWRTMRRFALSTLRDFGM----- 146

  Fly   162 GKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLI 226
            ||:..:::|:.|...........:|||.|.:..::.||||:|.:::...||..:||.|:......
Zfish   147 GKKLSEEKIVDETRYLREVFMKFEGQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVNKA 211

  Fly   227 EEGMRLFGEIHTVDYIPTMQCF--PSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLV 289
            ...:|:.|.  .|..|..|..|  |.|.|.: ::.:|....:|..|.:.|..:.:.:|.:.|.|:
Zfish   212 NMNIRMIGS--AVIQIYNMCPFLGPWIKTWR-QLMKNMESTRRQIQTLADVLQETLNPLDCRGLI 273

  Fly   290 DFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRV 354
            |.:|  |.|...:.|..:  |...:::.|:..:.:||:||.:|..|||.|..:.|.:.|:...||
Zfish   274 DSFL--IRKQNIQETGEK--DSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRV 334

  Fly   355 QDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVI 419
            |:|:|||:| .|.|..||.:.||.|::.|.|:.|.::|:||...|..:.||..|||.|..|:.|:
Zfish   335 QEEIDQVLG-GREPVAEDRKNLPYTDAVIHETQRLANILPLNLPHKTSCDVTFNGYFIKKGTCVL 398

  Fly   420 PLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFM 484
            ||:.||..|...||.|:.|.|..|:|.:|::.|.:.|:||..|||.|||:.||||||||||.|.:
Zfish   399 PLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSAGRRACLGESLARMELFLFFTSLL 463

  Fly   485 HCFDIALPEG--QPLPSLKGNVGATITPESFKVC 516
            ..|..:.|.|  :....|...||.|:.|...|:|
Zfish   464 QYFRFSPPPGASEDELDLTPVVGLTLNPSPHKLC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	168/471 (36%)
cyp2k8	NP_001124095.1	p450	58..497	CDD:278495	159/451 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910