DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and cyp2u1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001139036.1	Gene:	cyp2u1 / 556280	ZFINID:	ZDB-GENE-070730-1	Length:	533	Species:	Danio rerio

Alignment Length:	536	Identity:	186/536 - (34%)
Similarity:	282/536 - (52%)	Gaps:	69/536 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GLLALVTLL------QWLVRNYRELRKLPPGPWGLPVIG---------YLL--FMGSEK------ 73
            ||:|.|.:.      ||    ::....:||||...|::|         ::|  |:.:.|
Zfish    20 GLIAFVLVFYVLQEYQW----HQTYANIPPGPKPWPIVGNFGGFLVPPFILKRFVKNSKEFAKVV 80

  Fly    74 ------HTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NG 129
                  ....:|::|.||::||..:|.||.||::.|..:|:..  ..|.|:.||..|.:..: ..
Zfish    81 SNPLSPQAGLIEMSKLYGNIFSIFVGPQLMVVLTGYDAVRDAMLNHTETFSDRPHIPLVTIITKR 145

  Fly   130 YGIINST-GKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQ-------KRIMTEVHEFIGHLHASDG 186
            .||:.:. |.||:..|||.|..||.||.     |:..::       ..|.||:...|   ..:..
Zfish   146 KGIVFAPYGPLWRTNRRFCHSTLRSFGF-----GRMSLEPCIHEGLAIIKTELQSLI---ETAGP 202

  Fly   187 QPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHT----VDYIPTMQC 247
            ..:|::|:||.||||:|..:.:..||..:|.:||....|:..|:.:  .::|    |:..|.:..
Zfish   203 SGIDLTPLISNAVSNIISLMSLGQRFHHEDKEFRNMRDLMSHGLEI--SVNTSILLVNVFPWLYY 265

  Fly   248 FPSISTAKNKIAQNRAEMQ--RFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAE-LF 309
            .| ....|.   ..|||:.  .|.:.:|..|:.:.||.|.||.:|.||.|:...:.||:..| ||
Zfish   266 LP-FGVFKE---LRRAELDITAFLKRIIARHRATLDPENPRDFIDMYLVEMLAKQKEGSSEENLF 326

  Fly   310 DGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQ 374
            .    |:.|..:|.|||.||.:|...::||..::|...|....:||.|:|.|||..|:|::.|..
Zfish   327 S----EDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAVVGSERVPSLTDKS 387

  Fly   375 YLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFR 439
            .||.||:||:|.:|.:.:|||:..|..:...|..|:|||.|:.:||.:.|||.||.:||.|::|.
Zfish   388 SLPYTEATIMEVIRMTVVVPLSIPHMASETTEFRGFTIPKGTVIIPNLWSVHRDPTVWENPDDFN 452

  Fly   440 PSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNV 504
            ||||:|.:||:.:.:.|||||:|||:|:|:.||:|||||.|.|.|..|....|||...||:.|..
Zfish   453 PSRFLDDQGKILRKDCFIPFGLGRRVCMGEQLAKMELFLMFTSLMQTFTFRFPEGATAPSMHGRF 517

  Fly   505 GATITPESFKVCLKRR 520
            |.|:.|..|.||:|.|
Zfish   518 GLTLAPCPFTVCVKTR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	177/503 (35%)
cyp2u1	NP_001139036.1	p450	44..530	CDD:278495	177/503 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1505
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77704
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2702
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	1	1.100	-	-	O	PTHR24300
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4520
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900