DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and cyp1c1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001018446.2	Gene:	cyp1c1 / 553637	ZFINID:	ZDB-GENE-050522-501	Length:	523	Species:	Danio rerio

Alignment Length:	529	Identity:	161/529 - (30%)
Similarity:	258/529 - (48%)	Gaps:	36/529 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KFVLRQLQVQQD--GDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGS 71
            :|.|:...:.::  |..|..|:....:|..:....| |||....::| |||:..|::|..:.:|.
Zfish     4 EFGLKSSSIMREWSGQVQPALIASFIILFFLEACLW-VRNLTFKKRL-PGPFAWPLVGNAMQLGQ 66

  Fly    72 EKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNG--YGI 132
            ..|..|.:|||:||:::..|||....||::....||:..  ...||.|||:....|.::|  ...
Zfish    67 MPHITFSKLAKKYGNVYQIRLGCSDIVVLNGDAAIRKALVQHSTEFAGRPNFVSFQMISGGRSST 131

  Fly   133 INSTGKLWKDQRRFLHDKLRQFGMTYMGNGK---QQMQKRIMTEVHEFIGHLHASDGQPVDMSPV 194
            ..:..|.||..|:.....||.|.|......|   |.:....|..|.:|: .|.| ||:..:.:..
Zfish   132 FTNYSKQWKTHRKVAQSTLRAFSMANSQTRKTFEQHVVGEAMDLVQKFL-RLSA-DGRHFNPAHE 194

  Fly   195 ISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIA 259
            .:||.:||:|:|....|:..|||:||.....:.:.....|....||.:|.:|.||:   ....:.
Zfish   195 ATVAAANVVCALCFGKRYGHDDPEFRTLLGRVNKFGETVGAGSLVDVMPWLQSFPN---PVRSVY 256

  Fly   260 QN----RAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQ 320
            ||    ..|...:.:|.:..|:.::||:..||:.|..:..||..| |.|..:.|        :..
Zfish   257 QNFKTINKEFFNYVKDKVLQHRDTYDPDVTRDMSDAIIGVIEHGK-ESTLTKDF--------VES 312

  Fly   321 VIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILE 385
            .:.||..||.:|:.|.:.|:.:.:::.|....::|:::|:||||.|||:|||...|...::.|.|
Zfish   313 TVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIEDRCNLAYLDAFIYE 377

  Fly   386 SMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEG 448
            :||.:|.||:...||.|.||.:.|..||  ...:..||  ||:.||..|..|..|.||||:|..|
Zfish   378 TMRFTSFVPVTIPHSTTSDVTIEGLHIP--KDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENG 440

  Fly   449 KVRK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPE 511
            .:.|  ....:.|..|:|.|:|:.:|::|:|||.|..:|.........|.| |:..:.|..:.|.
Zfish   441 ALNKDLTNSVMIFSTGKRRCIGEQIAKVEVFLFSAILLHQCKFERDPSQDL-SMDCSYGLALKPL 504

  Fly   512 SFKVCLKRR 520
            .:.:..|.|
Zfish   505 HYTISAKLR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	148/477 (31%)
cyp1c1	NP_001018446.2	p450	50..504	CDD:278495	147/470 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820