Protein Alignment Cyp18a1 and CYP2W1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_011513742.1
• Gene: CYP2W1 / 54905
• HGNCID: 20243
• Length: 564
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 166/526 - (31%)
• Similarity: 258/526 - (49%)
• Gaps: 51/526 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYL-LFMGSEKHTRFMELAKQYGSLFS 89
            ||::|||||.|..||....::.....:.||||..||::|.| |...|::....|||:::||.:|:
Human     4 LLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFT 68

  Fly    90 TRLGSQLTVVMSDYKMIRECFR--REEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKL 151
            ..||.|.|||::.::.::|...  .:|...||.....|.: .|.||..|:|..|:..|:|....|
Human    69 VHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRAL 133

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            ...|:     |::.:..:|:.|:....|.|....|:|..:: ::..|.||:..:|:...||...|
Human   134 HSLGV-----GREPVADKILQELKCLSGQLDGYRGRPFPLA-LLGWAPSNITFALLFGRRFDYRD 192

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCF------PSISTAKNKIAQNRAEMQRFYQDVIDD 275
            |.|.....||:|.|.|.|.       |.:|.|      .::......:.:...|::...:.:::.
Human   193 PVFVSLLGLIDEVMVLLGS-------PGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEA 250

  Fly   276 HKRSFDPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            .:....|.: :...||..:     .:.:|.|.|   |...|...|...:|:..||.||...||.|
Human   251 RRPHVCPGDPVCSYVDALI-----QQGQGDDPE---GLFAEANAVACTLDMVMAGTETTSATLQW 307

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP--- 401
            ..:.|.|:|....|||:|||:|:|..|.|.:||.|.||.|.:.:.|..|..:::|    |.|
Human   308 AALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP----HVPRCT 368

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            ..|.:|.|:.:|.|:.||||:.||.:|...|:.|.:|.|..|:|..|...|.|.|:||..|||:|
Human   369 AADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVC 433

  Fly   467 LGDVLARMELFLFFASFMHCFDIALPEGQPLPSL----KGNVGATITPESFKVCLKRRPLGP--- 524
            :|:.|||.||||.||..:.    :.|:|.|.|:.    :..|.|:...::....|..|.|.|
Human   434 VGERLARTELFLLFAGLLQ----SSPQGPPAPTAGAAGRQRVAASSQRQAQVGVLSVRALHPPGP 494

  Fly   525 -TAADP 529
             |.|||
Human   495 GTPADP 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	134/446 (30%)
CYP2W1	XP_011513742.1	cytochrome_P450	63..459	CDD:477761	131/424 (31%)