Protein Alignment Cyp18a1 and cyp2d6

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001015719.1
• Gene: cyp2d6 / 548436
• XenbaseID: XB-GENE-855872
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 501
• Identity: 177/501 - (35%)
• Similarity: 273/501 - (54%)
• Gaps: 28/501 - (5%)

  Fly    34 LALVTLLQWLVRNYRELRK----LPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQYGSLFSTRLG 93
            |.::..|..|:.::.:.||    .||.|...|.:|.||.|. .:.|..|.:|:||||.:.|.|:.
 Frog    19 LGIIFTLLLLLLDFMKRRKPCTDFPPSPPSWPFVGNLLQMDFRDLHNSFKQLSKQYGDVMSLRVF 83

  Fly    94 SQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNGYG-----IINSTGKLWKDQRRFLHDKL 151
            .:.|||::.:::|:|..  :.|:...||.....:.|...|     ::.:.|:.|||.|||....|
 Frog    84 WKPTVVLNGFEVIKEALIQKSEDTADRPPFNLYEILGFVGNNKAVVLANYGQSWKDLRRFTLSTL 148

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     ||:.:::|:..|.........:..|.|.|...:|:.||||||||::...||..||
 Frog   149 RDFGM-----GKKSLEERVRDEAGYLCDAFQSEQGGPFDPHVLINTAVSNVICSIIFGERFEYDD 208

  Fly   217 PKFRRFNFLIEEGMRL-FGEI-HTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRS 279
            .||.:...||||.::. .|.: ..:..:|.....|.::   ....|.|..|.::.|::|::||::
 Frog   209 HKFLKLLCLIEESIKAESGPVPQIISSLPWSSKVPGLA---RLFFQPRIHMLQYLQEIINEHKQT 270

  Fly   280 FDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFM 344
            :|..:.||.:|.::.|::|||.      :.|...:::.|:....||||||.||..|||.|..:||
 Frog   271 WDSGHTRDFIDAFMLEMKKAKG------VKDSNFNDQNLLLTTADLFSAGSETTTTTLRWGLLFM 329

  Fly   345 LRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG 409
            |..|...|:||:|:|||:||.|.||:.|:..:|.|.:.|.|..|.:.|:||:..|...||..:.|
 Frog   330 LLYPDVQRKVQEEIDQVIGRTRKPTMGDVLQMPYTNAVIHEIQRYADIIPLSVPHMAYRDTHIKG 394

  Fly   410 YTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARM 474
            :.||.|:.::..::||..|..:||||.:|.|..|:|.:||..|.|.|:.|..|||:|||:.||||
 Frog   395 FFIPKGTVIMTNLSSVLKDEKVWEKPFQFYPEHFLDRDGKFVKREAFMAFSAGRRVCLGEQLARM 459

  Fly   475 ELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            ||||||.|.:..|...:|:|:|.............|..:|:|.|.|
 Frog   460 ELFLFFTSLLQRFSFQIPDGEPCLREDPVFVFLQVPHDYKICAKVR 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	169/472 (36%)
cyp2d6	NP_001015719.1	p450	52..501	CDD:306555	165/462 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1509
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2625
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm48967
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050