Protein Alignment Cyp18a1 and Cyp2w1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001153737.1
• Gene: Cyp2w1 / 545817
• MGIID: 3616076
• Length: 493
• Species: Mus musculus
• Alignment Length: 523
• Identity: 158/523 - (30%)
• Similarity: 253/523 - (48%)
• Gaps: 59/523 - (11%)

  Fly    26 LLMVFLG------LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQ 83
            :.::.||      ||.|..|||...|:.....:.||||..||.:|.|..:|..:..| .|||:::
Mouse     1 MALLLLGVWGILLLLGLWGLLQGCTRSPSLAPRWPPGPRPLPFLGNLHLLGVTQQDRALMELSER 65

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRR 145
            ||.:|:..||||.|||:|.|:::||..  ...|...||..|..|.: .|.||..|:|..|:..|:
Mouse    66 YGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQHIQRGGGIFFSSGARWRAGRQ 130

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            |....|:..|:.     :..|..:::.|:....|.|.:..|||:.:: ::..|..|:..:|:...
Mouse   131 FTVRTLQSLGVQ-----QPSMVGKVLQELACLKGQLDSYGGQPLPLA-LLGWAPCNITFTLLFGQ 189

  Fly   211 RFSIDDPKFRRFNFLIEEGMRLFGE--IHTVDYIPTMQCF-----PSISTAKNKIAQNRAEMQRF 268
            ||...||.|.....||::.|.|.|.  |...:..|.:..|     |.:|..:        |::..
Mouse   190 RFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGAFLRLHRPVLSKIE--------EVRTI 246

  Fly   269 YQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETI 333
            .:.:::..:   .|.........|:..:.:...|....::|.    |..::...:|:..||.||.
Mouse   247 LRTLLETRR---PPLPTGGPAQSYVEALLQQGQEDDPEDMFG----EANVLACTLDMVMAGTETT 304

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            ..||.|....|:::|....|||:|||:|:|..:||..|..:.||.|.:.:.|..|..:::|
Mouse   305 AATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEHQRALPYTSAVLHEVQRYITLLP---- 365

  Fly   399 HSP---TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFG 460
            |.|   ..|::|.||.:|.|:.||||:.||.:|...||.|.:|.|:.|:|.:|:..|...|:||.
Mouse   366 HVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGRFMKRGAFLPFS 430

  Fly   461 VGRRMCLGDVLARMELFLFFASFMHCFDIALPEG--------QPLPSLKGNVGATITPESFKVCL 517
            .|||:|:|..|||.||||.||..:..:.:..|.|        :|.|:.      |:.|.:..:|:
Mouse   431 AGRRVCVGKSLARTELFLLFAGLLQRYRLLPPPGLSPADLDLRPAPAF------TMRPPAQTLCV 489

  Fly   518 KRR 520
            ..|
Mouse   490 VPR 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	133/450 (30%)
Cyp2w1	NP_001153737.1	cytochrome_P450	66..487	CDD:477761	134/451 (30%)