Protein Alignment Cyp18a1 and Cyp2d11

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001098001.1
• Gene: Cyp2d11 / 545123
• MGIID: 88603
• Length: 504
• Species: Mus musculus
• Alignment Length: 512
• Identity: 168/512 - (32%)
• Similarity: 266/512 - (51%)
• Gaps: 31/512 - (6%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLL--FMGSEKHTRFMELAKQYGSLF 88
            |..|.:..:..:.|:..:.|:.....:.||||...||:|.||  .:|:..::.: :|..:||.:|
Mouse     9 LWSVAIFTVIFILLVDLMHRHQHWTSRCPPGPVPWPVLGNLLQVDLGNMPYSLY-KLQNRYGDVF 72

  Fly    89 STRLGSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTL----NGYGIINST-GKLWKDQRRF 146
            |.::|.:..||::..|.::|....  |:...||..|..:.|    ...|::.:. |..|::||||
Mouse    73 SLQMGWKPMVVINGLKAMKEVLLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWQEQRRF 137

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.||:     ||:.::..:..|.........|..||.::.:.:::.||.|||.||:.:.|
Mouse   138 SVSTLRNFGL-----GKKSLEDWVTKEARHLCDAFTAQAGQSINPNTMLNNAVCNVIASLIFARR 197

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIP-TMQCFP---SISTAKNKIAQNRAEMQRFYQDV 272
            |..:||...|...:::|   .|.||.  .:|| .:..||   .|....:.:.|.:........::
Mouse   198 FEYEDPYLIRMLKMLKE---CFTEIS--GFIPGVLNEFPIFLRIPGLADMVFQGQKSFMAILDNL 257

  Fly   273 IDDHKRSFDPNN-IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            :.:::.::||:. .|:|.|.:|.||||||  |.....|    ::|.|..|:.|||:|||.|..||
Mouse   258 LTENRTTWDPDQPPRNLTDAFLAEIEKAK--GNPESSF----NDENLRMVVGDLFTAGMVTTSTT 316

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |.|..:.|:.:|...||||.|:|.|:|:.:.|.:.|...:|.|.:.|.|..|...|.||......
Mouse   317 LSWALLLMILHPDVQRRVQQEIDAVIGQVQHPEMADQARMPYTNAVIHEVQRFGDIAPLPLPRIT 381

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            :||:|:..:.:..||.:||.::||..|..:||||..|.|..|:|.:|...|||.|:||..|.|.|
Mouse   382 SRDIEVQDFLVTKGSTLIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGHRSC 446

  Fly   467 LGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLG 523
            ||:.||||||||||...:..|.|::|:|||.||........:.|..:::|...|..|
Mouse   447 LGEALARMELFLFFTCLLQRFSISVPDGQPQPSNYRVHAIPVAPFPYQLCAVMREQG 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	149/441 (34%)
Cyp2d11	NP_001098001.1	CYP2D	68..495	CDD:410756	150/442 (34%)