Protein Alignment Cyp18a1 and Cyp2f4

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_062176.1
• Gene: Cyp2f4 / 54246
• RGDID: 2476
• Length: 491
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 175/528 - (33%)
• Similarity: 282/528 - (53%)
• Gaps: 65/528 - (12%)

  Fly    20 DGDAQHLLMVFLGLLAL-VTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAK 82
            ||.:..:|::.|.:::| :|...|      ...:|||||..||::|.||.:.|:. .|...:|:|
  Rat     2 DGVSTAILLLLLAVISLSLTFTSW------GKGQLPPGPKPLPILGNLLQLRSQDLLTSLTKLSK 60

  Fly    83 QYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQR 144
            .|||:|:..||.:..:|:|.|:.::|..  :.|||:||...| |.....|.||..|.|:.||..|
  Rat    61 DYGSVFTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYPIFFNFTKGNGIAFSDGERWKILR 125

  Fly   145 RFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMS 209
            ||....||.|||     ||:.:::||:.|....:..|..::|:|.|...::|.:|||:|||::..
  Rat   126 RFSVQILRNFGM-----GKRSIEERILEEGSFLLDVLRKTEGKPFDPVFILSRSVSNIICSVIFG 185

  Fly   210 TRFSIDDPKFRRFNFLIEEGMRL----FGEIHTV-----DYI--PTMQCFPSISTAKNKIAQNRA 263
            :||..||.:.......|.:..::    :||::.:     |::  |..:.|.:....|:.||::
  Rat   186 SRFDYDDERLLTIIHFINDNFQIMSSPWGEMYNIFPSLLDWVPGPHRRVFRNFGGMKDLIARS-- 248

  Fly   264 EMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH--EEQLVQVIIDLF 326
                     :.:|:.|.|||:.||.:|.:|.::.:.|.        |..:|  .:.|:....:|.
  Rat   249 ---------VREHQDSLDPNSPRDFIDCFLTKMVQEKQ--------DPLSHFNMDTLLMTTHNLL 296

  Fly   327 SAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSS 391
            ..|.||:.|||....:.:::.||...|||:|:|.||||.|:||:||...:|.|::.|.|..|.:.
  Rat   297 FGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVVGRSRMPTLEDRASMPYTDAVIHEVQRFAD 361

  Fly   392 IVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYF 456
            ::|:...|...||....|:.||.|:.||.|:|:||.|.:.::.|:||.|..|:|.....:|...|
  Rat   362 VIPMNLPHRVIRDTPFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDANQSFKKSPAF 426

  Fly   457 IPFGVGRRMCLGDVLARMELFLFFASFMHCF---------DIALPEGQPLPSLKGNVGATITPES 512
            :||..|||:|||:.|||||||::..|.:..|         ||.|   .||.|..||:     |..
  Rat   427 MPFSAGRRLCLGEPLARMELFIYLTSILQNFTLHPLVEPEDIDL---TPLSSGLGNL-----PRP 483

  Fly   513 FKVCLKRR 520
            |::|::.|
  Rat   484 FQLCMRIR 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	151/454 (33%)
Cyp2f4	NP_062176.1	Cyp2F	62..486	CDD:410762	152/455 (33%)