DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x6

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001013583.1	Gene:	cyp2x6 / 541440	ZFINID:	ZDB-GENE-050320-144	Length:	491	Species:	Danio rerio

Alignment Length:	510	Identity:	160/510 - (31%)
Similarity:	260/510 - (50%)	Gaps:	52/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFSTRLGSQL 96
            |:.:..||.:.:...::.:..||||..:|:.|.||.:......: |.:.|::||.:||...||:.
Zfish     7 LVVICILLIFFLIRVKKPKNFPPGPPPVPIFGSLLQLNLANPLKDFEKFAEKYGEIFSLYTGSRP 71

  Fly    97 TVVMSDYKMIRECF--RREEFTGRPDTPFM---QTLNGYGIINSTGKLWKDQRRFLHDKLRQFGM 156
            .|:::.:.:|:|..  :.::|:|||. .||   .|.|...::...|.:.|..|||....:|.||:
Zfish    72 AVILNSFAVIKEALVTKAQDFSGRPQ-DFMISHATENKGIVLADYGPVLKGHRRFALMTMRNFGL 135

  Fly   157 TYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRR 221
                 |||.|::||:.|:...:.:|..:.|:.||...:.....||||..|:...||..:....:.
Zfish   136 -----GKQSMEERILGEISHVVDYLDKNAGKRVDPHIMFHNVASNVISLLLFGCRFDYNSEFLQC 195

  Fly   222 FNFLIEEGMRLFGEIHTVDY----------IPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH 276
            :..||.|..::......:.|          :|..:.|..:...|:...:           :||:|
Zfish   196 YIQLINEISKIINGPWNMIYDTFPLLRILPLPFKKAFDHVKVIKSMNLK-----------LIDEH 249

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKN-----HEEQLVQVIIDLFSAGMETIKTT 336
            |.:..|...||.:|.||.|::|            |||     .|::|:..|:||..||.:||..|
Zfish   250 KSTRVPGEPRDFIDCYLDELDK------------GKNCVSTFSEDKLLMSIMDLHFAGTDTISNT 302

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVV-GRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            ||...::::.:|:...:.|.|:|.|: |:.|: ..||...:|.|.:.|.|..|.::.|||:..||
Zfish   303 LLTAFLYLMNHPEVQVKCQQEIDDVLEGKDRV-MYEDRHNMPYTLAVIHEVQRVANTVPLSVFHS 366

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|||.||.||:||.|:.:||.:..|..:...|:.|.||.|:.|::.:|:..|||.||||..|.||
Zfish   367 TTRDTELMGYSIPKGTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQFEKPEAFIPFSTGLRM 431

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |||:.||||||||.|.:.:..|....|.....|......|.|:||:.:::.::||
Zfish   432 CLGEGLARMELFLIFVALLRRFQFEWPVDAGKPDYTPVFGLTLTPKPYRMHIRRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	155/484 (32%)
cyp2x6	NP_001013583.1	p450	36..479	CDD:278495	150/472 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720