DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp18a1 and Cyp2j16

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_578474.1	Gene:	Cyp2j16 / 502969	RGDID:	1561242	Length:	503	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	160/493 - (32%)
Similarity:	255/493 - (51%)	Gaps:	24/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNYRELRK---LPPGPWGLPVIGYLLFMG---SEKHTRFMELAKQYGSLFSTR 91
            ||.|:|.|  |:.:|.:.|:   .|||||.||.:|.|....   |..|.|..:..|:||:|.|..
  Rat    22 LLTLLTFL--LLADYLKNRRPNNYPPGPWRLPFVGNLFQFDLNISHLHLRIQQFVKKYGNLISLD 84

  Fly    92 LGSQLTVVMSDYKMIRECF--RREEFTGRPDTPF-MQTLNGYGIINSTGKLWKDQRRFLHDKLRQ 153
            .|:...||::...:|:|..  ..:.|..||..|. .:.....||..:....||:||||....|:.
  Rat    85 FGNISVVVITGLPLIKEALINNEQNFLKRPIVPSRYRVFKDNGIFFANVHKWKEQRRFALTMLKN 149

  Fly   154 FGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPK 218
            ||:     ||:.:::.|..|.|..:..:....|||.|....|:.||||:|||:....||..||.:
  Rat   150 FGL-----GKKSLEQCIQEEAHHLVEVIGEEKGQPFDPHFRINNAVSNIICSITFGERFEYDDSQ 209

  Fly   219 FRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPN 283
            |:....|.:|.:.....:.:|.|......|..:......:.:|..:::....::||.|::.::|:
  Rat   210 FQELLKLADEVICSEASMTSVLYNVFPLIFKYLPGPHQTVFKNWEKLKSIVANMIDRHRKDWNPD 274

  Fly   284 NIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNP 348
            ..||.||.:|.|:.|...:.|.:      .:||.|:...:|||.||.||..|||.|..:::..||
  Rat   275 EPRDFVDAFLTEMTKYPDKTTTS------FNEENLIATTLDLFFAGTETTSTTLRWALLYITLNP 333

  Fly   349 KEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIP 413
            :...:|..|:|:|:|..|||:.:|...:|.|.:.|.|.:|..:|:||......|.|..|.|:.:|
  Rat   334 EVQEKVHSEIDRVIGHGRLPSTDDQDAMPYTNAVIHEVLRMGNIIPLNVPREVTADSTLAGFHLP 398

  Fly   414 AGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFL 478
            .|..::..:.::|.||..|..|:.|.|..|:: .|:.:|.:.|:||.||:|.|.|:.||:.|||:
  Rat   399 KGKMILTNLTALHRDPKEWATPDTFNPEHFLE-NGQFKKRDSFLPFSVGKRACPGEKLAKSELFI 462

  Fly   479 FFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            ||.:.|..|....|..:.| |||...|.::.|.|:::|
  Rat   463 FFTALMQNFTFKAPTNEKL-SLKLRKGLSLYPVSYRIC 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	152/469 (32%)
Cyp2j16	XP_578474.1	p450	44..499	CDD:278495	151/467 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820