DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2aa8

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_021325465.1	Gene:	cyp2aa8 / 450060	ZFINID:	ZDB-GENE-041010-183	Length:	499	Species:	Danio rerio

Alignment Length:	503	Identity:	158/503 - (31%)
Similarity:	265/503 - (52%)	Gaps:	28/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MVFLGLLALVTLL-QWLVRNYR---ELRKLPPGPWGLPVIGYL-LFMGSEKHTRFMELAKQYGSL 87
            :.|.|:..:::|: .:|:..:|   ...:.||||..||.:|.| :|:  :....|:....|||.:
Zfish    10 LAFAGMTLILSLIFMFLLEIFRIHSFKSRFPPGPSPLPFVGNLPVFL--KNPMEFIRSLSQYGEM 72

  Fly    88 FSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTL-NGYGIINST-GKLWKDQRRFLHDK 150
            .:..||.:.|::::..::.:|...::.|.|:|..|.:..: ||.||:..| ...|:.||||....
Zfish    73 TTIYLGRKPTIMLNTVQLAKEVLIQDAFAGKPSLPVLDWVSNGLGIVMVTFNHSWRQQRRFALHT 137

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     |::.::.|::.|....|..|....|:.|:....:..|.||||||::...||..|
Zfish   138 LRNFGL-----GRKSVESRVLEESQYLIAELLKKKGKSVNPHHALQNAFSNVICSIVFGDRFDYD 197

  Fly   216 DPKFRRFNFLIEEGMRLFGEI--HTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKR 278
            |.:|..|..::.:.|.|.|..  ...::.|.::.||.   ...||.:|..|:..|:|..:.:||:
Zfish   198 DKRFEHFLEILGKSMILTGSTAGQIFNFAPIIKHFPG---PHQKIKKNADELSGFFQHEVKEHKK 259

  Fly   279 SFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVF 343
            :.||.:.||.:|.||.|:||.|:..      |...|:|.|:....|||.||.::..||..|..:|
Zfish   260 TLDPGSPRDYIDAYLLEMEKQKSNK------DSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLF 318

  Fly   344 MLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELN 408
            :::||....|...|:.||:|..|||::||...||.|.:|:.|..|.:::.|....|...:..:|.
Zfish   319 LIQNPDVQERCHKEIVQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQ 383

  Fly   409 GYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLAR 473
            ||.:|.|:.:|..:.::..:...|:.|:.|.|..|:|..|:..|.|.||||.:|.|:|||:.|||
Zfish   384 GYDLPRGTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSLGVRVCLGETLAR 448

  Fly   474 MELFLFFASFMHCFDIAL-PEGQPLPSLKGNVGATITPESFK-VCLKR 519
            .|||||..:.:.....:| |:.:|: .:.|.:.....|::|. :|..|
Zfish   449 TELFLFITALLQRIRFSLPPDAKPM-DMDGILSVLRYPQNFSFICCSR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/469 (32%)
cyp2aa8	XP_021325465.1	p450	40..491	CDD:306555	151/467 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820