DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2k16

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001005963.2	Gene:	cyp2k16 / 449790	ZFINID:	ZDB-GENE-041010-37	Length:	502	Species:	Danio rerio

Alignment Length:	519	Identity:	177/519 - (34%)
Similarity:	272/519 - (52%)	Gaps:	38/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFM 78
            |.|...|    .|:.|| ||.||..|.:| |:..:..: ||||..||::|.||.:...| |....
Zfish     8 LHVSSTG----TLICFL-LLLLVAYLLFL-RSQSDENE-PPGPKPLPLLGNLLMLDVNKPHLSLC 65

  Fly    79 ELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLW 140
            |:|||:|.:|....|.:..||::.||.:::..  ..|.|..|...| |.....|:|||.:.|:.|
Zfish    66 EMAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFHDFTKGHGIIFANGESW 130

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICS 205
            ::.|||....||.|||     ||::::::|:.|...........:|:|.:.:.:::.|.|:||.|
Zfish   131 REMRRFALTNLRDFGM-----GKKKIEEKIIEETCHLREEFEKFEGKPFETAQLMNYAASSVISS 190

  Fly   206 LMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQN-RAEMQRFY 269
            ::...||...||:.|.......|.:||.|......|    ..||.:    ..:.:| |..|:..:
Zfish   191 IVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQLY----NMFPFL----GPLLKNWRQLMKNLH 247

  Fly   270 QDV------IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSA 328
            .|:      ::...::.:..::|..||.:|  :.|..||  |:...|...||:.|:..:.:||.|
Zfish   248 LDIEEISELVNGLHQTLNHQDLRGFVDSFL--VRKQYAE--DSGEKDSHFHEQNLIYTVGNLFVA 308

  Fly   329 GMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIV 393
            |.:|..|||.|..:.|.:.|....|||:|:|||:| .|.|..||.:.||.|::.|.|:.|.::||
Zfish   309 GTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIG-GRQPVSEDRKNLPYTDAVIHETQRLANIV 372

  Fly   394 PLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIP 458
            |::..|..:.|:..|||.|..|:.:.||:.||..|.:.||.|..|.|:.|:|.:|:..|.:.|:|
Zfish   373 PMSIPHMTSSDITFNGYFIKKGTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMP 437

  Fly   459 FGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG--QPLPSLKGNVGATITPESFKVCLKRR 520
            |..|||:|||:.||||||||||.|.:..|....|.|  :....|...||.|:.|.:.|:|..:|
Zfish   438 FSAGRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVGFTLNPIAHKLCAVKR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	162/475 (34%)
cyp2k16	NP_001005963.2	p450	58..497	CDD:278495	153/456 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1505
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2702
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960