Protein Alignment Cyp18a1 and Cyp2c68

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001034644.2
• Gene: Cyp2c68 / 433247
• MGIID: 3612287
• Length: 491
• Species: Mus musculus
• Alignment Length: 510
• Identity: 156/510 - (30%)
• Similarity: 253/510 - (49%)
• Gaps: 48/510 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLFS 89
            :|::.|..|.|::|  |..|:.|  ..|||||..||:|| |.|....:........:|.||.:|:
Mouse     6 VLVLCLSFLLLLSL--WRQRSAR--GNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKIYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKL 151
            ...|||..|::..|:.::|.|  ..|||:||...| |.:...|.||..|.|.:||..|.|..:.|
Mouse    67 LYFGSQPIVILHGYEAMKEAFIDYGEEFSGRGRIPVFDKVSKGKGIGFSHGNVWKATRVFTVNTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||:.::.::..|....:..|..::|.|.|...:|..|..|||||::...||...|
Mouse   132 RNLGM-----GKRTIETKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKD 191

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYI---PTMQCFPSIST-------AKNKIAQNRAEMQRFYQD 271
            ..|          :.|.|:::....|   |..|.|.::..       :.||..:|...::.:..:
Mouse   192 KDF----------LSLIGKVNECTEILSSPECQIFNAVPILIDYCPGSHNKFLKNHTWIKSYLLE 246

  Fly   272 VIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE----EQLVQVIIDLFSAGMET 332
            .|.:|:.|.|..|.||.||::|  |::.:..|.:        |.    |.|..::.||...|.||
Mouse   247 KIKEHEESLDVTNPRDFVDYFL--IQRRQKNGIE--------HMDYTIEHLATLVTDLVFGGTET 301

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            :.:|:.:..:.::::.....:||:|:|.|:||||.|.::|..::|.|.:.:.|..|...:.|...
Mouse   302 LSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGV 366

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            .|..|.|.:...|.||.|:.|:..:.||..|...:..||.|.|..|:|..|..:|.:||:||..|
Mouse   367 VHEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFMPFSAG 431

  Fly   463 RRMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            :|:|:|:.|||||||||..:.:..|.: .|.:.:.:.....:.|.:..|.:|::|
Mouse   432 KRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	134/447 (30%)
Cyp2c68	NP_001034644.2	CYP2C-like	61..485	CDD:410758	135/448 (30%)