DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x8

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001002187.1	Gene:	cyp2x8 / 431734	ZFINID:	ZDB-GENE-040704-28	Length:	451	Species:	Danio rerio

Alignment Length:	446	Identity:	137/446 - (30%)
Similarity:	221/446 - (49%)	Gaps:	40/446 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFSTRLGSQL 96
            |:.:..||.:|:...:..:..||||..||:.|.||........: |...|::||::||...||:.
Zfish     7 LVLICILLVFLLIRIQRPKNFPPGPSPLPIFGNLLHFNLANPLKDFERFAEKYGNIFSLYTGSRP 71

  Fly    97 TVVMSDYKMIRECF--RREEFTGRPDTPFMQTL---NGYGIINSTGKLWKDQRRFLHDKLRQFGM 156
            .|.::.:.:|:|..  :.::|:|||....:..|   .|. ::...|.||||.|||....||.||:
Zfish    72 AVFLNSFAVIKEALVTKAQDFSGRPQDFMISHLTECKGV-VLADYGPLWKDHRRFALMTLRNFGL 135

  Fly   157 TYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRR 221
                 |||.|::||:.|:...:.:|..:.|:.||...:.....||||..::...||..:....:.
Zfish   136 -----GKQSMEERILGEISHVVCYLDKNIGKTVDPQVMFHNVASNVISLVLFGRRFDYNSETLQC 195

  Fly   222 FNFLIEEGMRLFGEIHTVDY----------IPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDH 276
            :..||.|..::......:.|          :|..:.|..:...|....:           :||:|
Zfish   196 YIQLITEISKILNGPWNMIYDTLPFLRILPLPFKKGFDHVKVLKGMNLK-----------LIDEH 249

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341
            |.:..|...||.:|.||.|::|.|.|   ...|.    |:||:..|:||:.||.:|...|||...
Zfish   250 KSTRVPGKPRDFIDCYLDELDKRKNE---VSTFS----EDQLLMYILDLYFAGTDTTSNTLLTAF 307

  Fly   342 VFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVE 406
            ::::.:|:...:.|.|:|.|:......:.||...:|.|.:.|.|..|.::.|||:..|..|||.|
Zfish   308 LYLMNHPEVQVKCQQEIDDVLEGKDQVSYEDRDNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTE 372

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            |.||:||.|:.:||.:..|..:...|:.|.||.|:.|::.:|:..|||.||||..|
Zfish   373 LMGYSIPKGTLIIPNLTIVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFSTG 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	133/425 (31%)
cyp2x8	NP_001002187.1	p450	28..428	CDD:278495	132/423 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720