DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c54

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_996260.1	Gene:	Cyp2c54 / 404195	MGIID:	3642960	Length:	490	Species:	Mus musculus

Alignment Length:	511	Identity:	172/511 - (33%)
Similarity:	265/511 - (51%)	Gaps:	48/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFS 89
            :|::.|.|..|..|..|  |...|..||||||..||:||.:|.:..:...: |..|::.||.:::
Mouse     4 ILVLVLTLSCLFLLSLW--RQSYERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSRVYGPVYT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKL 151
            ..||.:.|||:..|:.::|..  ..:.|.||...| |.:..||.||..|.|.:||:.|.|....|
Mouse    67 LYLGRKPTVVLHGYEAVKEALVDHGDVFAGRGRLPVFDKATNGMGIGFSNGSVWKNTRHFSLMTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||:.::.|:..|....:..|..::|.|.|.:.::..|..|||||::...||   |
Mouse   132 RNLGM-----GKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRF---D 188

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ-C--FPSI----STAKNKIAQNRAEMQRFYQDVID 274
            .|.|.|..|:|:    ..||..:...|.:| |  ||::    ..:.|:..:|.|.::.|..:.|.
Mouse   189 YKDRDFLNLLEK----LDEISKILSTPWLQVCNTFPALLDYCPGSHNQFFKNYAYIKNFLLEKIR 249

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            :||.|.|....||.:|::|.   |...|..:..|   ||:.|.|...:.|||..|.|::.|||.:
Mouse   250 EHKESLDVTIPRDFIDYFLI---KGAQEDDNHPL---KNNFEHLAITVTDLFIGGTESMSTTLRY 308

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRD 404
            ..:.:|:.|....:||:|::.|:|:||.|.::|..::|.|.:.|.|..|...:||....|..|.|
Mouse   309 ALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTNAMIHEVQRFIDLVPNNLPHEVTCD 373

  Fly   405 VELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGD 469
            ::...|.||.|:.||..::||..|...:..||:|.|..|:|..||.:|.:||:||..|:|:|.|:
Mouse   374 IKFRNYFIPKGTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAGE 438

  Fly   470 VLARMELFLFFASFMHCFDIALPEGQPL---------PSLKGNVGATITPESFKVC 516
            .|||||||||..|.:..|::     :||         |.|   :|....|.:|::|
Mouse   439 GLARMELFLFLTSILQNFNL-----KPLVHPKDIDITPML---IGLGSVPPAFQLC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	162/483 (34%)
Cyp2c54	NP_996260.1	p450	30..487	CDD:278495	162/483 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820