Protein Alignment Cyp18a1 and Cyp2c54

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_996260.1
• Gene: Cyp2c54 / 404195
• MGIID: 3642960
• Length: 490
• Species: Mus musculus
• Alignment Length: 511
• Identity: 172/511 - (33%)
• Similarity: 265/511 - (51%)
• Gaps: 48/511 - (9%)

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFS 89
            :|::.|.|..|..|..|  |...|..||||||..||:||.:|.:..:...: |..|::.||.:::
Mouse     4 ILVLVLTLSCLFLLSLW--RQSYERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSRVYGPVYT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKL 151
            ..||.:.|||:..|:.::|..  ..:.|.||...| |.:..||.||..|.|.:||:.|.|....|
Mouse    67 LYLGRKPTVVLHGYEAVKEALVDHGDVFAGRGRLPVFDKATNGMGIGFSNGSVWKNTRHFSLMTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |..||     ||:.::.|:..|....:..|..::|.|.|.:.::..|..|||||::...||   |
Mouse   132 RNLGM-----GKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRF---D 188

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ-C--FPSI----STAKNKIAQNRAEMQRFYQDVID 274
            .|.|.|..|:|:    ..||..:...|.:| |  ||::    ..:.|:..:|.|.::.|..:.|.
Mouse   189 YKDRDFLNLLEK----LDEISKILSTPWLQVCNTFPALLDYCPGSHNQFFKNYAYIKNFLLEKIR 249

  Fly   275 DHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            :||.|.|....||.:|::|.   |...|..:..|   ||:.|.|...:.|||..|.|::.|||.:
Mouse   250 EHKESLDVTIPRDFIDYFLI---KGAQEDDNHPL---KNNFEHLAITVTDLFIGGTESMSTTLRY 308

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRD 404
            ..:.:|:.|....:||:|::.|:|:||.|.::|..::|.|.:.|.|..|...:||....|..|.|
Mouse   309 ALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTNAMIHEVQRFIDLVPNNLPHEVTCD 373

  Fly   405 VELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGD 469
            ::...|.||.|:.||..::||..|...:..||:|.|..|:|..||.:|.:||:||..|:|:|.|:
Mouse   374 IKFRNYFIPKGTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAGE 438

  Fly   470 VLARMELFLFFASFMHCFDIALPEGQPL---------PSLKGNVGATITPESFKVC 516
            .|||||||||..|.:..|::     :||         |.|   :|....|.:|::|
Mouse   439 GLARMELFLFLTSILQNFNL-----KPLVHPKDIDITPML---IGLGSVPPAFQLC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	149/448 (33%)
Cyp2c54	NP_996260.1	CYP2C-like	61..485	CDD:410758	150/449 (33%)