DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x7

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001243106.1	Gene:	cyp2x7 / 402847	ZFINID:	ZDB-GENE-110114-2	Length:	491	Species:	Danio rerio

Alignment Length:	510	Identity:	167/510 - (32%)
Similarity:	268/510 - (52%)	Gaps:	39/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGS-EKHTRFMELAKQYGSLFS 89
            :|.|.:.:|..:.|:.:|:|..|. :..||||..:|:.|.||.:.. :....|..||::||::||
Zfish     1 MLEVSVLILICIFLVFFLIRIKRP-KNFPPGPPPVPIFGNLLQINMVDPLKEFERLAEKYGNIFS 64

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNG-YGIINST-GKLWKDQRRFLHDK 150
            ...||:..|.::::::|:|..  :.::|:|||....:..|.| .|::.:. |.||||.|||....
Zfish    65 LYTGSKPAVFLNNFEVIKEALVTKAQDFSGRPQDLMISHLTGNKGVVLADYGPLWKDHRRFALMT 129

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||.||:     |||.|::||:.|:...:..|..:.|:.||...:.....||||..::...||..:
Zfish   130 LRNFGL-----GKQSMEERILGEISHIVDFLDKNTGKTVDPQIMFHNIASNVINLVLFGCRFDYN 189

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVDY----------IPTMQCFPSISTAKNKIAQNRAEMQRFYQ 270
            :...|.:...|.|.:|:......:.|          :|..:.|.::...|   :.||
Zfish   190 NEFLRGYIQRIAENLRILNGPWNMIYDTFPLLRILPLPFKKAFDNVKIIK---SMNR-------- 243

  Fly   271 DVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKT 335
            .:||:||.:..|...||.:|.||.|::|.|   .....|.    |:||:..|:|:..||.:|...
Zfish   244 KLIDEHKSTRVPGQPRDFIDCYLDELDKVK---NCVSTFS----EDQLIMNIMDMSFAGTDTTSN 301

  Fly   336 TLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHS 400
            |||...::::.:|:...:.|.|:|.|:......|.||...:|.|.:.|.|..|.::||||:..|.
Zfish   302 TLLAAFLYLMNHPEVQVKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANIVPLSVLHC 366

  Fly   401 PTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRM 465
            .|||.||.||:||.|:.:||.:..|..:...|:.|.||.|:.|::.:|:..|||.||||..|.|:
Zfish   367 TTRDTELMGYSIPKGTVIIPNLTVVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFSTGPRV 431

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |||:.||||||||.|.:.:..|....||....|......|.|:||:.:::.::||
Zfish   432 CLGEGLARMELFLIFVTLLRRFQFVWPEDAGKPDYTPVFGLTMTPKPYRMHIRRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	158/477 (33%)
cyp2x7	NP_001243106.1	p450	36..479	CDD:278495	153/465 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720