DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2p10

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_958919.1	Gene:	cyp2p10 / 399485	ZFINID:	ZDB-GENE-040120-1	Length:	497	Species:	Danio rerio

Alignment Length:	504	Identity:	177/504 - (35%)
Similarity:	268/504 - (53%)	Gaps:	39/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFST 90
            :::|   |.:..||...::| :..:..|||||.||.||.|..:...| |.:|.|.|::||.:||.
Zfish    15 ILIF---LCVFLLLSDYIKN-KAPKNFPPGPWSLPFIGDLHHIDPNKIHLQFTEFAEKYGKIFSF 75

  Fly    91 RLGSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTLNG--YGIINSTGKLWKDQRRFLHDKL 151
            ||.....||::.|.:::|.:.:  :....||..|....:.|  .|::.|:|..||.||||....|
Zfish    76 RLFGSRIVVLNGYNLVKEVYTQQGDNLADRPTLPITSAIIGDNRGLVASSGYKWKHQRRFALTTL 140

  Fly   152 RQFGMTYMGNGKQQMQKRIMTE---VHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFS 213
            |.||:     ||:.::..|..|   ::|.|.:   ..|:|.:...:::.|||||||.|:...||.
Zfish   141 RNFGL-----GKKNLELSINFECGFLNEAISN---EQGRPFNPRLLLNNAVSNVICVLVFGNRFE 197

  Fly   214 IDDPKFRRFNFLIEEGMRLFGEI--HTVDYIP-TMQCFPSISTAKNKIAQNRAEMQRFYQDVIDD 275
            ..|..|:.....|.|.:.|.|.|  |..:..| .||..|.   ...|:......:..|.::.:::
Zfish   198 YSDHHFQNLLNKINESVYLEGSIFVHLYNMFPWLMQLLPG---PHKKLITLWQRVTDFVREKVNE 259

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAK---AEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            |:..:||:::||.:|.:|.|:||.|   |.|.|.         |.|....:|||.||.||..|||
Zfish   260 HRVDYDPSSLRDYIDCFLAEMEKHKDDTAAGFDV---------ENLCMCTLDLFVAGTETTSTTL 315

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .|..::|::.|:...:||.|:|.|||..|.|:..|...:|.|.:.|.|..|..:|:||....:.:
Zfish   316 YWGLLYMIKYPEIQAKVQQEIDAVVGSSRQPSGSDRDNMPYTNAVIHEIQRMGNIIPLNVVRTTS 380

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            .|..:..|:||.|:.||..:.||..|.:.||.|..|.|..|:|.|||.|:.:.|:||.:|:|:||
Zfish   381 EDTRIEKYSIPKGTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCL 445

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:.||||||||||:|.:..|..:.|.|.. |||...:|.|..|:.:|:|
Zfish   446 GEQLARMELFLFFSSVLQRFTFSPPAGVE-PSLDFKMGFTRCPKPYKLC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	172/477 (36%)
cyp2p10	NP_958919.1	p450	38..493	CDD:278495	171/475 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1505
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2702
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870