DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2k18

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_005163790.1	Gene:	cyp2k18 / 393484	ZFINID:	ZDB-GENE-040426-1584	Length:	503	Species:	Danio rerio

Alignment Length:	523	Identity:	191/523 - (36%)
Similarity:	279/523 - (53%)	Gaps:	44/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFM 78
            ||....|.....|::|| :|.||:......:..:|    ||||..||::|.||.:. :.....|.
Zfish     8 LQFASTGTLLGALLLFL-VLYLVSSGSGSQKEGKE----PPGPKPLPLLGNLLTLDLTRAFDTFF 67

  Fly    79 ELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNG-YGIINSTGKLW 140
            ||:|.||::|...||.:.|||:..||.::|..  ..|.|..|...|..:.:|. :||:.|.|:.|
Zfish    68 ELSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFRIMNDEHGIVFSNGENW 132

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICS 205
            |:.|||....||.|||     ||:..:::|:.|:|...|.....:|:|.|.:..::.||||:|.|
Zfish   133 KEMRRFALSNLRDFGM-----GKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTEPVNYAVSNIISS 192

  Fly   206 LMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST-AKNK------IAQNRA 263
            ::..:||...||:|........|.:|:.|.|....|    ..||.:.. .|||      |.|:||
Zfish   193 IVYGSRFEYTDPQFTEMVDRANENVRVGGSISMGLY----NMFPWLGPFLKNKRIVVRNIIQSRA 253

  Fly   264 EMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKN----HEEQLVQVIID 324
            :|.:....:::    :.:||:.|..||.:|  |.|...|.:      ||.    |.|.|:..:.:
Zfish   254 QMTKLITALLE----TLNPNDPRGFVDSFL--IHKLSDEKS------GKKNSYFHNENLMMNVAN 306

  Fly   325 LFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRR 389
            ||.||.:|..|||.|..:.|.:.|:...|||:|:|:|:| .|.|.:||.:.||.|::.|.|..|.
Zfish   307 LFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPAVEDRKKLPYTDAVIHEIQRF 370

  Fly   390 SSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPE 454
            ::||||...|:.:.|:..|||.|..|:.||||:.||..|.:.||||..|.|..|:|.:|:..|.:
Zfish   371 ANIVPLNLPHTTSCDITFNGYFIKKGTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRD 435

  Fly   455 YFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG--QPLPSLKGNVGATITPESFKVCL 517
            .|:||..|||:|||:.||||||||||.|.:..:....|.|  :....|||.||.|:.|...|:|.
Zfish   436 AFMPFSAGRRICLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCA 500

  Fly   518 KRR 520
            .||
Zfish   501 IRR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	178/479 (37%)
cyp2k18	XP_005163790.1	p450	63..499	CDD:278495	169/457 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910