Protein Alignment Cyp18a1 and cyp2k18

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_005163790.1
• Gene: cyp2k18 / 393484
• ZFINID: ZDB-GENE-040426-1584
• Length: 503
• Species: Danio rerio
• Alignment Length: 519
• Identity: 188/519 - (36%)
• Similarity: 276/519 - (53%)
• Gaps: 36/519 - (6%)

  Fly    15 LQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG-SEKHTRFM 78
            ||....|.....|::|| :|.||:......:..:|    ||||..||::|.||.:. :.....|.
Zfish     8 LQFASTGTLLGALLLFL-VLYLVSSGSGSQKEGKE----PPGPKPLPLLGNLLTLDLTRAFDTFF 67

  Fly    79 ELAKQYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLNG-YGIINSTGKLW 140
            ||:|.||::|...||.:.|||:..||.::|..  ..|.|..|...|..:.:|. :||:.|.|:.|
Zfish    68 ELSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFRIMNDEHGIVFSNGENW 132

  Fly   141 KDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICS 205
            |:.|||....||.|||     ||:..:::|:.|:|...|.....:|:|.|.:..::.||||:|.|
Zfish   133 KEMRRFALSNLRDFGM-----GKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTEPVNYAVSNIISS 192

  Fly   206 LMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST-AKNK------IAQNRA 263
            ::..:||...||:|........|.:|:.|.|....|    ..||.:.. .|||      |.|:||
Zfish   193 IVYGSRFEYTDPQFTEMVDRANENVRVGGSISMGLY----NMFPWLGPFLKNKRIVVRNIIQSRA 253

  Fly   264 EMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSA 328
            :|.:....:::    :.:||:.|..||.:|......:..|.....|    |.|.|:..:.:||.|
Zfish   254 QMTKLITALLE----TLNPNDPRGFVDSFLIHKLSDEKSGKKNSYF----HNENLMMNVANLFVA 310

  Fly   329 GMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIV 393
            |.:|..|||.|..:.|.:.|:...|||:|:|:|:| .|.|.:||.:.||.|::.|.|..|.::||
Zfish   311 GTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPAVEDRKKLPYTDAVIHEIQRFANIV 374

  Fly   394 PLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIP 458
            ||...|:.:.|:..|||.|..|:.||||:.||..|.:.||||..|.|..|:|.:|:..|.:.|:|
Zfish   375 PLNLPHTTSCDITFNGYFIKKGTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMP 439

  Fly   459 FGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEG--QPLPSLKGNVGATITPESFKVCLKRR 520
            |..|||:|||:.||||||||||.|.:..:....|.|  :....|||.||.|:.|...|:|..||
Zfish   440 FSAGRRICLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	160/441 (36%)
cyp2k18	XP_005163790.1	cytochrome_P450	73..498	CDD:477761	161/442 (36%)