DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2aa3

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_938183.2	Gene:	cyp2aa3 / 386638	ZFINID:	ZDB-GENE-031030-8	Length:	496	Species:	Danio rerio

Alignment Length:	504	Identity:	159/504 - (31%)
Similarity:	267/504 - (52%)	Gaps:	35/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKH-----TRFMELAKQYGS 86
            |.:||||:.||....:.:.:|:  |:.||||..||      |:|:..|     ..|:....|||.
Zfish    15 LTLFLGLIILVLFEIFRIHSYK--RRTPPGPTPLP------FVGTIPHFLKNPLGFIRSMSQYGD 71

  Fly    87 LFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTLN-GYGIINST-GKLWKDQRRFLHD 149
            :.:..||.:..:.::..::.:|...::.|:|:|..|.::.:: |:||...| ...|:.||||...
Zfish    72 MSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGFGIAMVTFNHSWRQQRRFALH 136

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .|:.||:     ||:.::.|::.|....|..:...:|:|||....|..||||:|||::...||..
Zfish   137 TLKNFGL-----GKKSVEDRVLEESRYLIAEMLKDEGKPVDPHHPIQNAVSNIICSIVFGDRFEY 196

  Fly   215 DDPKFRRFNFLIEEGMRLFGEI--HTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHK 277
            ::.:|.....::.|.:.|.|..  ...:.:|.::.||.   ...||.:|..::..|..|.:::|:
Zfish   197 NNKRFEYLLKMLNETIMLAGSASGRIFNLVPFIKHFPG---PHQKIKKNTDDLLIFLGDEVEEHR 258

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINV 342
            ::.||.:.||.:|.||.||||.|...      |...||..|:....|||.||.:|.:||:.|..:
Zfish   259 KTLDPGSPRDFIDAYLLEIEKQKFNK------DSTFHEGNLLASAGDLFMAGTDTTETTIRWGLL 317

  Fly   343 FMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVEL 407
            |:::||....|..:|:.||:|..|||:::|...||.|.:|:.|..|..:|:|: ..|......:|
Zfish   318 FLIQNPDVQERCHEEIVQVLGYDRLPSMDDRDRLPYTLATVHEIQRYGNIIPI-LIHETILPTKL 381

  Fly   408 NGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLA 472
            .||:||.|:.::..|.::....:.|:.|:.|.|..|::....: |||.||.|.:|.|.|||::||
Zfish   382 QGYSIPQGTTIVTNIQAIFSSKDHWKHPDSFNPENFLEDRHFI-KPESFIMFSLGPRSCLGEILA 445

  Fly   473 RMELFLFFASFMHCFDIAL-PEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |.|||||..|.:.....:. |:.:|: .:.|..|...:|::|.|..:.|
Zfish   446 RTELFLFITSLLQRIHFSWPPDAKPI-DMDGIFGLVHSPQAFNVICRSR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	149/472 (32%)
cyp2aa3	NP_938183.2	p450	40..480	CDD:278495	146/462 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820