Protein Alignment Cyp18a1 and Cyp2t4

DIOPT Version :9

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001093654.1
• Gene: Cyp2t4 / 384724
• MGIID: 2686296
• Length: 503
• Species: Mus musculus
• Alignment Length: 520
• Identity: 179/520 - (34%)
• Similarity: 266/520 - (51%)
• Gaps: 55/520 - (10%)

  Fly    27 LMVFLGLLALVTLLQW--LVRNYRELRK-LPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSL 87
            |.:.|.||.|:.||.|  :||...:::| |||||..||::|.||.:.|....| .|||:..:|.:
Mouse    13 LALLLLLLILMLLLWWGGVVRRQAQMQKDLPPGPAPLPLLGNLLQLQSGDLDRVLMELSSHWGPV 77

  Fly    88 FSTRLGSQLTVVMSDYKMIREC--FRREEFTGR-PDTPFMQTLNGYGIINSTGKLWKDQRRFLHD 149
            |:..||....||:..|:.:|:.  .:.:.|:|| ....|.:...|.||:.|.|..|...|.|...
Mouse    78 FTVWLGPLPAVVLCGYEALRDALVLQADAFSGRGAMAVFDRFTCGNGIVFSNGPRWHSLRNFALG 142

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .||:.|:     |:..::.||:.|....:....|:.|.|.|...::..|||||||:::...|:..
Mouse   143 VLRELGV-----GRSTIEDRILEEAACVLDEFQATMGAPFDPQQLLDSAVSNVICTVVFGKRYDY 202

  Fly   215 DDPKFRRF------NFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFY 269
            .||:|||.      ||.|....  :.||:.:        |||    |....|:|.:|..|::.|.
Mouse   203 GDPEFRRLLNLFSDNFCIMSSR--WAEIYNM--------FPSFMDWIPGPHNRIFKNFQELRLFI 257

  Fly   270 QDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNH--EEQLVQVIIDLFSAGMET 332
            .:.|..|.:|......||.:|.:|.:::|        |..|.::|  :|.||....|||..|.||
Mouse   258 SEQIQWHWQSRQTGEPRDFIDCFLDQMDK--------EQQDLESHFQDETLVMTTHDLFFGGTET 314

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            ..|||.:..:.||:.|:...:||:|||..|||...|.|||...||.|.:.:.|..|..|::||..
Mouse   315 TSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTWAPRIEDRARLPYTNAVLHEIQRFISVLPLGL 379

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            ..:.||||.|..:.:..|:.||||:.|.|.||..::.|:.|.|:.|:|..|:.:..:.|:||.:|
Mouse   380 PRALTRDVNLKNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDHGEFQNNDAFMPFALG 444

  Fly   463 RRMCLGDVLARMELFLFFASFMHCFDIALPEGQPL-----PSLK--GNVGATITPESFKVCLKRR 520
            :|||||..|||.|:|||..:.:..|.: ||.|.|.     |...  |||     |.:|::.|..|
Mouse   445 KRMCLGAGLARSEIFLFLTAILQKFSL-LPVGSPANINLNPQCTGLGNV-----PPAFQLRLVAR 503

  Fly   521  520
            Mouse   504  503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	165/485 (34%)
Cyp2t4	NP_001093654.1	p450	63..498	CDD:278495	155/463 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010