Protein Alignment Cyp18a1 and Cyp49a1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 541
• Identity: 126/541 - (23%)
• Similarity: 216/541 - (39%)
• Gaps: 116/541 - (21%)

  Fly    44 VRNYRELRKLPPGPWGLPVIG----YLLFMG-----------SEKHTRFMELAKQYGSLFSTRLG 93
            ||.|.|:    |||:.||:||    :...:|           :|.|..:.::|| .|.|    :|
  Fly    97 VRPYSEV----PGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAK-VGGL----IG 152

  Fly    94 SQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTLNGY-------------GIINSTGKLWKDQRR 145
            ....:.:.|...||..|::||  ..|..|.|.:|..|             |:|...|..|:..|:
  Fly   153 HPDLLFVFDGDEIRNIFKKEE--AMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQ 215

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVH----EFIGHLH----ASDGQPVDMSPVISVAVSNV 202
            .:...|.|          .|..|:.:..::    ||:|.:.    ..|..|.:....:.......
  Fly   216 EVQHILLQ----------PQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALES 270

  Fly   203 ICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDY--------IPTMQCFPSISTAKNKIA 259
            :..:.:.||.....|:..      ||..::...|:|..:        :|..:.:|:
  Fly   271 VGRVSLDTRLGCLSPEGS------EEAQQIIEAINTFFWAVPELELRMPLWRIYPT--------- 320

  Fly   260 QNRAEMQRFYQDVID--DHKRSFDPNNIRDLVDFYLCE----IEKAKAEGTDAELFDGKNHEEQL 318
                   :.|:..:.  |...:....||...:|....:    :.|::|:.:..|....|....:|
  Fly   321 -------KAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKL 378

  Fly   319 VQVI-IDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIED--LQYLPITE 380
            ..:: :|||..|::|...........:.:||.:.:::.||| |.|..||...|..  |:.:|...
  Fly   379 AAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDEL-QKVFPHREADINQNVLEQMPYLR 442

  Fly   381 STILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFI- 444
            :.:.|::|...:| :|...|...|..:|||.:|.|:|||.....|..||..:.:|:.|.|.|::
  Fly   443 ACVKETLRMRPVV-IANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLK 506

  Fly   445 ---DTEG------KVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSL 500
               |..|      |:. |...:|||.|||||:|...|.:||....|.....:.::...|:    .
  Fly   507 QSTDAAGCPHANQKIH-PFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGE----F 566

  Fly   501 KGNVGATITPES---FKVCLK 518
            ...|.:|..|:|   ||:.|:
  Fly   567 VYRVNSTYIPQSPLNFKLTLR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	108/480 (23%)
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	110/488 (23%)