DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2x12

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_005166578.1	Gene:	cyp2x12 / 325939	ZFINID:	ZDB-GENE-030131-4664	Length:	496	Species:	Danio rerio

Alignment Length:	517	Identity:	159/517 - (30%)
Similarity:	261/517 - (50%)	Gaps:	30/517 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFME-LAKQYGSLFST 90
            ::..|.||.|...|.:|....|..:..||||..:|..|.||.:......:.:: .|:.|||::..
Zfish     1 MLTALVLLCLGAFLLYLQVRIRRPKDFPPGPAPVPFFGNLLQLNRINPIKDLDKFAQHYGSIYGI 65

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINST-GKLWKDQRRFLHDKL 151
            .:||:..||::..|||:|..  :..||.|||:...:..: ...|:|.:. |:.|::.|||....|
Zfish    66 YIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGVIMADYGESWREHRRFALTTL 130

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.||:     ||:.|::||:.||......|..|.|:.:|...:...|.||:|.|::..:||:..|
Zfish   131 RNFGL-----GKKSMEQRILEEVKHICLLLEESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKD 190

  Fly   217 PKFRRFNFLIEEGMRLFGEIHT----VDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHK 277
            ..|:.....:|:..::  .|.|    .:..|.::.||   ....|......::.|....|:::||
Zfish   191 EYFQTLIQTMEKLTKI--AIGTWAMLYEIAPVLRIFP---LPFWKAFHYFEKITRHSLKVVEEHK 250

  Fly   278 RSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINV 342
            :||.....:||:|.||.|::|...:.|   .||    |.|:|.::.|||.||.||...||..:.:
Zfish   251 KSFVAGEPKDLIDCYLEEMKKRADQRT---TFD----EAQMVTLLFDLFLAGTETTSNTLRTLTL 308

  Fly   343 FMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVEL 407
            :::.:.....:.|.|:|:|:|.....|.||...:...::.|.|..|.:.||||...|:...|.:|
Zfish   309 YLMTHTHIQEQCQREIDEVLGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQL 373

  Fly   408 NGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLA 472
            .||:||.|:.:||.::|...:.:.|:.|.||.|..|::.:|:..|.|.|:||..|.|:|||:.||
Zfish   374 RGYSIPKGTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNEAFMPFSAGPRVCLGENLA 438

  Fly   473 RMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPTAADPHHMRN 534
            ||||||...:.:..|.:..|:....|......|.|.:.:.:.:.::.|..|.|    |...|
Zfish   439 RMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPMIVELRTPGET----HEYAN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	147/471 (31%)
cyp2x12	XP_005166578.1	p450	28..466	CDD:278495	145/454 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820